慢性疲劳综合征中针对核膜抗原的自身抗体。
Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome.
作者信息
Konstantinov K, von Mikecz A, Buchwald D, Jones J, Gerace L, Tan E M
机构信息
Autoimmune Disease Center and Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
出版信息
J Clin Invest. 1996 Oct 15;98(8):1888-96. doi: 10.1172/JCI118990.
Abstract
We have identified and partially characterized the autoantibodies in sera of 60 patients with chronic fatigue syndrome. Approximately 52% of the sera were found to react with nuclear envelope antigens. The combination of nuclear rim staining observed in immunofluorescence microscopy and immunoblot analysis of highly purified nuclear envelope proteins provided initial characterization of these autoantibodies. Further characterization showed that some sera immunoprecipitated the in vitro transcription and translation product of a human cDNA clone encoding the nuclear envelope protein lamin B1. The autoantibodies were of the IgG isotype. The occurrence of autoantibodies to a conserved intracellular protein like lamin B1 provides new laboratory evidence for an autoimmune component in chronic fatigue syndrome.
摘要
我们已经鉴定并部分表征了60例慢性疲劳综合征患者血清中的自身抗体。大约52%的血清被发现与核膜抗原发生反应。免疫荧光显微镜下观察到的核边缘染色与高度纯化的核膜蛋白的免疫印迹分析相结合，为这些自身抗体提供了初步表征。进一步的表征表明，一些血清免疫沉淀了编码核膜蛋白核纤层蛋白B1的人类cDNA克隆的体外转录和翻译产物。这些自身抗体属于IgG同种型。针对像核纤层蛋白B1这样保守的细胞内蛋白产生自身抗体，为慢性疲劳综合征中的自身免疫成分提供了新的实验室证据。
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