Ozaki T, Hillmann A, Lindner N, Blasius S, Winkelmann W
Department of Orthopaedies, Westfalische Wilhelms-University, Münster, Germany.
J Cancer Res Clin Oncol. 1996;122(10):625-8. doi: 10.1007/BF01221195.
This study was undertaken to analyse metastases of patients with intermediate- or high-grade chondrosarcomas. Out of 24 intermediate-grade tumours, 5 (21%) developed metastases, as did 6 of 10 high-grade tumours (60%) (P = 0.04). Four patients developed pulmonary metastasis only, 5 developed both pulmonary metastases and metastases of the other sites. Two patients showed a rare metastatic pattern: bone metastases only. The metastasis rate in the primary chondrosarcoma (42%) was higher than that in the secondary chondrosarcomas (0%) (P = 0.03). The metastasis rate was higher in patients with local recurrence (86%) than in those without local recurrence (19%) (P = 0.01). In 5 of 6 patients who had a local relapse and metastasis, the interval between the two relapses was a few months.
本研究旨在分析中、高级别软骨肉瘤患者的转移情况。在24例中级别的肿瘤中，5例（21%）发生转移，10例高级别肿瘤中有6例（60%）发生转移（P = 0.04）。4例患者仅发生肺转移，5例患者同时发生肺转移和其他部位转移。2例患者表现出罕见的转移模式：仅发生骨转移。原发性软骨肉瘤的转移率（42%）高于继发性软骨肉瘤（0%）（P = 0.03）。局部复发患者的转移率（86%）高于无局部复发患者（19%）（P = 0.01）。在6例发生局部复发和转移的患者中，有5例两次复发的间隔为几个月。
