1型人类免疫缺陷病毒现场分离株的中和血清型不能通过基因亚型预测。世界卫生组织艾滋病毒分离与鉴定网络。
Neutralization serotypes of human immunodeficiency virus type 1 field isolates are not predicted by genetic subtype. The WHO Network for HIV Isolation and Characterization.
作者信息
Weber J, Fenyö E M, Beddows S, Kaleebu P, Björndal A
机构信息
Department of Communicable Diseases, Imperial College School of Medicine at St. Mary's, London, United Kingdom.
出版信息
J Virol. 1996 Nov;70(11):7827-32. doi: 10.1128/JVI.70.11.7827-7832.1996.
Abstract
Human immunodeficiency virus type 1 (HIV-1) primary isolates from four geographical locations in Thailand, Brazil, Rwanda, and Uganda, representing genetic subtypes A, B, C, D, and E, were examined for autologous and heterologous neutralization by panels of human HIV+ polyclonal plasma. In independent linked experiments in three laboratories using diverse methodologies and common reagents, no defined pattern of genetic subtype-specific neutralization was observed. Most plasma tested were broadly cross-neutralizing across two or more genetic subtypes, although the titer of neutralization varied across a wide range. We conclude that the genetic subtypes of HIV-1 are not classical neutralization serotypes.
摘要
对来自泰国、巴西、卢旺达和乌干达四个地理位置的1型人类免疫缺陷病毒（HIV-1）原代分离株进行了检测，这些分离株代表了基因亚型A、B、C、D和E，采用一组人类HIV阳性多克隆血浆进行自体和异源中和试验。在三个实验室使用不同方法和通用试剂进行的独立关联实验中，未观察到明确的基因亚型特异性中和模式。尽管中和效价在很宽的范围内变化，但大多数检测的血浆对两种或更多种基因亚型具有广泛的交叉中和作用。我们得出结论，HIV-1的基因亚型不是经典的中和血清型。
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