卡波西肉瘤相关疱疹病毒（人类疱疹病毒8型）在受感染细胞和病毒颗粒中的DNA大小及构象。
The size and conformation of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) DNA in infected cells and virions.
作者信息
Renne R, Lagunoff M, Zhong W, Ganem D
机构信息
Howard Hughes Medical Institute and Department of Microbiology, University of California, San Francisco 94143, USA.
出版信息
J Virol. 1996 Nov;70(11):8151-4. doi: 10.1128/JVI.70.11.8151-8154.1996.
Abstract
The genome of a novel human herpesvirus has been detected in specimens of Kaposi's sarcoma (KS) and in several AIDS-related lymphoproliferative disorders. Here we examine the size and genomic conformation of the DNA of this virus (known as KS-associated herpesvirus or human herpesvirus 8) in latently and lytically infected cells and in virions. Pulsed-field gel electrophoresis of viral DNA shows that the viral genome is similar in size to those of other gammaherpesviruses (160 to 170 kb). As with Epstein-Barr virus, KS-associated herpesvirus DNA is stably maintained in latently infected B cells as episomal monomer circles and induction from latency is associated with the selective accumulation of linear genomic forms.
摘要
在卡波西肉瘤（KS）标本以及几种与艾滋病相关的淋巴增生性疾病中，已检测到一种新型人类疱疹病毒的基因组。在此，我们研究了这种病毒（称为KS相关疱疹病毒或人类疱疹病毒8）的DNA在潜伏感染和裂解感染细胞以及病毒颗粒中的大小和基因组构象。病毒DNA的脉冲场凝胶电泳显示，该病毒基因组的大小与其他γ疱疹病毒相似（160至170 kb）。与爱泼斯坦-巴尔病毒一样，KS相关疱疹病毒DNA在潜伏感染的B细胞中作为游离单体环稳定维持，从潜伏状态的诱导与线性基因组形式的选择性积累有关。
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