Fox M W, Onofrio B M, Onofrio B M, Hanssen A D
Department of Neurosurgery, Mayo Graduate School of Medicine, Rochester, Minnesota, USA.
J Neurosurg. 1996 Nov;85(5):793-802. doi: 10.3171/jns.1996.85.5.0793.
One hundred twenty-four patients with degenerative lumbar stenosis underwent decompression with fusion (32 patients) and without fusion (92 patients) during a 30-month period between 1986 and 1988. Patient-reported satisfaction at a mean follow-up period of 5.8 years (range 4.6-6.8 years) revealed a 79% good or fair outcome and a 21% poor outcome (26 patients). Seven patients (6%) developed lumbar instability, three patients (2%) developed new stenosis at an adjacent unoperated level, and three patients (2%) developed a new disc herniation between 2 and 5 years after surgery. Progressive postoperative spondylolisthesis occurred in 31% of patients with normal preoperative alignment (mean 7.8 mm, range 2-20 mm) and in 73% of patients with preoperative subluxation (mean 5.1 mm, range 2-13 mm) in whom fusion was not attained. Radiological progression did not correlate well with patient-reported outcome. The major conclusions from this study are the following: 1) the majority of patients respond well to this surgery, but complication (22%) and late deterioration (10%) rates are not insignificant; 2) radiological instability is common after decompression for degenerative lumbar spinal stenosis, but this correlates poorly with clinical outcome; 3) there are no definitive clinical or radiological factors that preoperatively predict patients at risk for a poor outcome; 4) post-operative radiological instability is more likely to occur when the following criteria are present: preoperative spondy-degenerated L-4 or a markedly degenerated L-3 disc; and when a radical and extensive decompression greater than one level is planned; and 5) the group at greatest risk for a poor outcome consists of those patients with normal preoperative alignment who do not suffer slippage following surgery.
1986年至1988年的30个月期间,124例退行性腰椎管狭窄症患者接受了减压融合手术(32例)和非融合减压手术(92例)。平均随访5.8年(范围4.6 - 6.8年)时患者报告的满意度显示,79%的患者结果为良好或尚可,21%的患者结果较差(26例)。7例患者(6%)出现腰椎不稳,3例患者(2%)在未手术的相邻节段出现新的椎管狭窄,3例患者(2%)在术后2至5年出现新的椎间盘突出。术前排列正常的患者中,31%(平均7.8 mm,范围2 - 20 mm)术后发生进行性椎体滑脱;术前有半脱位的患者中,73%(平均5.1 mm,范围2 - 13 mm)在未实现融合的情况下术后发生进行性椎体滑脱。影像学进展与患者报告的结果相关性不佳。本研究的主要结论如下:1)大多数患者对该手术反应良好,但并发症发生率(22%)和晚期病情恶化率(10%)并非微不足道;2)退行性腰椎管狭窄减压术后影像学不稳定很常见,但与临床结果相关性较差;3)术前没有明确的临床或影像学因素可预测患者预后不良的风险;4)当出现以下标准时,术后影像学不稳定更有可能发生:术前L4椎体退变或L3椎间盘明显退变;计划进行大于一个节段的广泛减压;5)预后不良风险最高的人群包括术前排列正常且术后未发生滑脱的患者。