Centers for Disease Control and Prevention, Atlanta, GA 30341, USA.
Contraception. 2013 Sep;88(3):382-6. doi: 10.1016/j.contraception.2012.10.034. Epub 2012 Dec 4.
Prostate-specific antigen (PSA) is a biomarker of recent semen exposure. There is currently only limited information on whether topical vaginal products affect PSA assays. We investigated this question using various dilutions of several vaginal products (lubricants and spermicides) and the Abacus ABAcard for PSA detection.
Pooled semen controls and various dilutions of nonoxynol-9 (N9), carboxymethyl cellulose (CMC), Replens, Gynol 2, K-Y jelly, Astroglide, Surgilube, combined with pooled semen dilutions, were tested for PSA using the Abacus ABAcard.
N9 (2% with saline) and CMC did not appear to affect the results of testing with the ABAcard, but not all semen dilutions were tested. The other products (including Replens and Gynol, which is 2% N9 with propylene glycol, K-Y, Astroglide and Surgilube) at some of the dilutions tested either affected or gave invalid results with PSA testing using the ABAcard. Both Gynol 2 and K-Y at 1:10 dilution gave false-positive results.
Some vaginal products affect PSA results obtained by using the semiquantitative ABAcard. In vivo confirmation is necessary to further optimize PSA detection when topical vaginal products are present.
前列腺特异性抗原（PSA）是近期精液暴露的生物标志物。目前，关于局部阴道产品是否会影响 PSA 检测的信息有限。我们使用几种阴道产品（润滑剂和杀精剂）和 Abacus ABAcard 对 PSA 检测进行了各种稀释，以研究这个问题。
将 Pooled semen 对照品和不同稀释度的非诺孕醇-9（N9）、羧甲基纤维素（CMC）、Replens、Gynol 2、K-Y 果冻、Astroglide、Surgilube 与 Pooled semen 稀释液混合，使用 Abacus ABAcard 检测 PSA。
N9（2%生理盐水）和 CMC 似乎不会影响 ABAcard 的检测结果，但未对所有精液稀释液进行检测。其他产品（包括 Replens 和 Gynol，它是 2%的 N9 与丙二醇的混合物，K-Y、Astroglide 和 Surgilube）在一些测试的稀释度下，要么影响了 PSA 检测结果，要么给出了无效结果。Gynol 2 和 K-Y 在 1:10 的稀释度下都给出了假阳性结果。
一些阴道产品会影响使用半定量 ABAcard 获得的 PSA 结果。当存在局部阴道产品时，需要进行体内确认，以进一步优化 PSA 检测。
