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甘氨酰胺核糖核苷酸合成酶与超氧化物歧化酶（可溶性）之间的共线性。

Synteny between glycinamide ribonucleotide synthetase and superoxide dismutase (soluble).

作者信息

Moore E E, Jones C, Kao F T, Oates D C

出版信息

Am J Hum Genet. 1977 Jul;29(4):389-96.

PMID:889603
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1685382/
Abstract

The auxotrophic mutant ade -C derived from Chinese hamster ovary cell CHO-K1 lacks the enzyme glycinamide ribonucleotide synthetase and requires exogenous supplement of purines for growth. Cells from this mutant were fused with normal human lymphocytes, and the resulting hybrids were isolated in purine-deficient medium. A total of 32 primary clones and 49 secondary clones were analyzed for various isozyme markers. Cytogenetic analysis with chromosome banding was also performed in some hybrid clones. The results provide evidence indicating that glycinamide ribonucleotide synthetase is syntenic with superoxide dismutase (soluble) and is located on human chromosome 21.

摘要

源自中国仓鼠卵巢细胞CHO-K1的营养缺陷型突变体ade -C缺乏甘氨酰胺核糖核苷酸合成酶，需要外源补充嘌呤才能生长。将该突变体的细胞与正常人淋巴细胞融合，并在嘌呤缺乏的培养基中分离得到杂交细胞。对总共32个初级克隆和49个次级克隆进行了各种同工酶标记分析。还对一些杂交克隆进行了染色体显带的细胞遗传学分析。结果提供了证据表明甘氨酰胺核糖核苷酸合成酶与超氧化物歧化酶（可溶性）同线，并位于人类21号染色体上。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee02/1685382/e4eaedf9d5c7/ajhg00208-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee02/1685382/2f62d4878057/ajhg00208-0065-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee02/1685382/699570e1fb3f/ajhg00208-0066-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee02/1685382/e4eaedf9d5c7/ajhg00208-0068-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee02/1685382/2f62d4878057/ajhg00208-0065-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee02/1685382/699570e1fb3f/ajhg00208-0066-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee02/1685382/e4eaedf9d5c7/ajhg00208-0068-a.jpg

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