头发化学物质可能会增加乳腺癌风险：来自 14 项研究的 210319 名受试者的荟萃分析。
Hair chemicals may increase breast cancer risk: A meta-analysis of 210319 subjects from 14 studies.
机构信息
Department of Oncology, The Second Ward, The PLA Navy Anqing Hospital, Anqing, Anhui Province, China.
出版信息
PLoS One. 2021 Feb 4;16(2):e0243792. doi: 10.1371/journal.pone.0243792. eCollection 2021.
BACKGROUND
The association between personal hair dye use and breast cancer risk is currently debated. The aim of this work is to investigate the association between the use of hair care products and breast cancer risk in women.
METHODS
Based on the PRISMA-IPD statement, the PubMed, Embase, Cochrane Library, Web of Science, OVID and Scopus databases were used to identify eligible studies published from inception to 22 April 2020. A pooled odds ratio (OR) with a 95% confidential interval (CI) was calculated to assess this correlation via fixed- or random-effect Mantel-Haenszel models using a heterogeneity Chi2 test with a significance level of p<0.1. All statistical tests were performed using StataSE software (version 12.0).
RESULTS
The analyzed data comprised 14 eligible studies with 210319 unique subjects. The pooled results suggested that there was a significant association between the use of hair dyes and breast cancer occurrence (pooled OR = 1.07; 95% CI, 1.01-1.13). Regarding the individual analysis regarding the different types of hair chemicals, permanent hair dye users (pooled OR = 1.08; 95% CI, 1.03-1.14) and rinse users (pooled OR = 1.17; 95% CI, 1.02-1.35) were both found to have a significantly elevated breast cancer risk compared to natural hair subjects, whereas there was an insignificant relationship between the use of semipermanent hair dyes (pooled OR = 1.09; 95% CI, 0.92-1.28) and straighteners (pooled OR = 1.04; 95% CI, 0.96-1.14) and breast cancer risk. No impact on the overall correlation between hair dyes and breast cancer risk due to race (White vs non-White) (pooled OR = 1.05; 95% CI, 0.86-1.29), timing of use (<10 years vs ≥10 years) (pooled OR = 0.96; 95% CI, 0.85-1.08) or dye color (Darker than natural hair vs Lighter than natural hair) (pooled OR = 0.91; 95% CI, 0.62-1.32) was found.
CONCLUSIONS
Chemicals in hair dyes may play a role in breast carcinogenesis and increase breast cancer risk.
背景
个人使用染发剂与乳腺癌风险之间的关联目前存在争议。本研究旨在调查女性使用护发产品与乳腺癌风险之间的关系。
方法
基于 PRISMA-IPD 声明，检索了从成立到 2020 年 4 月 22 日发表的 PubMed、Embase、Cochrane 图书馆、Web of Science、OVID 和 Scopus 数据库中的合格研究。使用固定或随机效应 Mantel-Haenszel 模型，通过异质性 Chi2 检验（显著性水平 p<0.1）计算合并比值比（OR）及其 95%置信区间（CI）来评估这种相关性。所有统计检验均使用 StataSE 软件（版本 12.0）进行。
结果
分析数据包含 14 项合格研究，涉及 210319 名独特受试者。合并结果表明，染发剂的使用与乳腺癌发生之间存在显著关联（合并 OR = 1.07；95%CI，1.01-1.13）。关于不同类型头发化学物质的个体分析，永久性染发剂使用者（合并 OR = 1.08；95%CI，1.03-1.14）和冲洗染发剂使用者（合并 OR = 1.17；95%CI，1.02-1.35）与自然头发使用者相比，乳腺癌风险显著升高，而半永久性染发剂（合并 OR = 1.09；95%CI，0.92-1.28）和直发器（合并 OR = 1.04；95%CI，0.96-1.14）的使用与乳腺癌风险之间无显著关系。由于种族（白种人 vs 非白种人）（合并 OR = 1.05；95%CI，0.86-1.29）、使用时间（<10 年 vs ≥10 年）（合并 OR = 0.96；95%CI，0.85-1.08）或染发剂颜色（深于自然头发颜色 vs 浅于自然头发颜色）（合并 OR = 0.91；95%CI，0.62-1.32），染发剂与乳腺癌风险之间的总体相关性没有受到影响。
结论
染发剂中的化学物质可能在乳腺癌发生中发挥作用，并增加乳腺癌风险。
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