Dubois A
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA.
Emerg Infect Dis. 1995 Jul-Sep;1(3):79-85. doi: 10.3201/eid0103.950302.
During the past decade, Helicobacter pylori has become recognized as one of the most common human pathogens, colonizing the gastric mucosa of almost all persons exposed to poor hygienic conditions from childhood. It also is often found, albeit with a lower frequency, in groups of high socioeconomic status. H. pylori causes chronic active gastritis and is a major factor in the pathogenesis of duodenal ulcers and, to a lesser extent, gastric ulcers. In addition, the presence of this bacterium is now recognized as a risk factor for gastric adenocarcinoma and lymphoma. Nevertheless, most infections appear without clinical consequences. In this second decade of intensive research, it is important to understand why H. pylori is sometimes a dangerous pathogen, and to determine how it can be eradicated in those at highest risk for severe disease.
在过去十年中，幽门螺杆菌已被公认为最常见的人类病原体之一，几乎所有自幼暴露于卫生条件差的环境中的人的胃黏膜都会被其定植。在社会经济地位较高的人群中也经常发现幽门螺杆菌，尽管感染频率较低。幽门螺杆菌会引发慢性活动性胃炎，并且是十二指肠溃疡发病机制中的主要因素，在胃溃疡发病中所起作用相对较小。此外，现在已认识到这种细菌的存在是胃腺癌和淋巴瘤的危险因素。然而，大多数感染似乎并无临床症状。在深入研究的第二个十年里，了解幽门螺杆菌为何有时会成为危险病原体，以及确定如何在罹患严重疾病风险最高的人群中根除该菌，这很重要。
