The effect of 2,4-dichlorophenol on lipid peroxidation in tissues of guinea pigs with different ascorbic acid intake.

Chlorinated phenols are widely used in the manufacture of biocides and wood preservatives. 2,4-dichlorophenol administered perorally 3 times a week at a dose of 40 mg in 0.2 ml of olive oil per kg of body weight to guinea pigs increased lipid peroxidation in liver and adrenals after 2 weeks of treatment. A high intake of ascorbic acid (50 mg/animal/day) significantly decreased lipid peroxidation in the liver of 2, 4-dichlorophenol treated guinea pigs in comparison to guinea pigs with low ascorbic acid intake (2 mg/animal/day). 2,4-dichlorophenol accumulation was also decreased in the liver of animals with high ascorbic acid intake. Increased daily intake of vitamin C to persons involved in production and use of chlorophenoxy herbicides is recommended.