Clerhata D, Kováciková Z, Veningerová M, Lukácsová M, Ginter E
Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
Ind Health. 1996;34(4):415-9. doi: 10.2486/indhealth.34.415.
Chlorinated phenols are widely used in the manufacture of biocides and wood preservatives. 2,4-dichlorophenol administered perorally 3 times a week at a dose of 40 mg in 0.2 ml of olive oil per kg of body weight to guinea pigs increased lipid peroxidation in liver and adrenals after 2 weeks of treatment. A high intake of ascorbic acid (50 mg/animal/day) significantly decreased lipid peroxidation in the liver of 2, 4-dichlorophenol treated guinea pigs in comparison to guinea pigs with low ascorbic acid intake (2 mg/animal/day). 2,4-dichlorophenol accumulation was also decreased in the liver of animals with high ascorbic acid intake. Increased daily intake of vitamin C to persons involved in production and use of chlorophenoxy herbicides is recommended.
氯酚广泛用于制造杀虫剂和木材防腐剂。每周给豚鼠经口投喂3次2,4 - 二氯酚，剂量为每千克体重40毫克，溶于0.2毫升橄榄油中，治疗2周后，肝脏和肾上腺中的脂质过氧化增加。与低抗坏血酸摄入量（每只动物每天2毫克）的豚鼠相比，高抗坏血酸摄入量（每只动物每天50毫克）显著降低了2,4 - 二氯酚处理的豚鼠肝脏中的脂质过氧化。高抗坏血酸摄入量的动物肝脏中2,4 - 二氯酚的积累也减少。建议从事氯苯氧基除草剂生产和使用的人员增加每日维生素C摄入量。
