Nakagawa S, Yoshikawa H, Onda T, Kawana T, Iwamoto A, Taketani Y
Department of Obstetrics and Gynecology, University of Tokyo, Japan.
Cancer. 1996 Nov 1;78(9):1935-41.
Despite the fact that approximately ten types of human papillomavirus (HPV) are associated with cervical carcinoma, the question of whether the HPV type present in cervical carcinoma is related to clinical behavior had yet to be answered when this study was conducted.
The presence and type of HPV were determined by polymerase chain reaction (PCR)-based assay (LI-PCR) in 146 cervical carcinomas. Clinical features were compared among the following 4 groups: Group 18 (27 patients positive for HPV 18), Group 16 (55 patients positive for HPV 16), Group O (47 patients positive for the other HPV types), and Group N (17 HPV negative patients). Special focus was given to histologic type, patient's age at onset, and patient survival as indicators of the biologic properties of the carcinomas.
Occurrence of adenocarcinoma or adenosquamous carcinoma was higher in Group 18 (48%) than in Group 16 (13%) or Group O (9%) (P < 0.0005). The mean age of the patients at onset was different among the 4 groups (Group 18, 46 years; Group 16, 55 years; Group O, 63 years; Group N, 58 years) (P < 0.005). The prevalence of HPV 18, HPV 16, and other forms of the virus was most frequent in ages < 40, 50-79, and > 60, respectively. Group 18 had a poorer prognosis than Group 16, O, or N. A statistical difference in the 5-year survival rate was found between Groups 18 and 16 (52% vs. 74%, P < 0.05).
These data suggest that the HPV type present in cervical carcinoma is related to clinical behavior.
尽管大约十种人类乳头瘤病毒（HPV）与宫颈癌相关，但在开展本研究时，宫颈癌中存在的HPV类型是否与临床行为相关这一问题仍未得到解答。
采用基于聚合酶链反应（PCR）的检测方法（LI-PCR）对146例宫颈癌患者进行HPV检测，确定其是否存在及类型。对以下四组患者的临床特征进行比较：18型组（27例HPV 18阳性患者）、16型组（55例HPV 16阳性患者）、O组（47例其他HPV类型阳性患者）和N组（17例HPV阴性患者）。特别关注组织学类型、患者发病年龄和患者生存率，将其作为癌症生物学特性的指标。
18型组腺癌或腺鳞癌的发生率（48%）高于16型组（13%）或O组（9%）（P<0.0005）。四组患者的平均发病年龄不同（18型组，46岁；16型组，55岁；O组，63岁；N组，58岁）（P<0.005）。HPV 18、HPV 16和其他病毒形式分别在<40岁、50 - 79岁和>60岁人群中最为常见。18型组的预后比16型组、O组或N组差。18型组和16型组的5年生存率存在统计学差异（52%对74%，P<0.05）。
这些数据表明，宫颈癌中存在的HPV类型与临床行为相关。
