Dalekos G N, Elisaf M S, Papagalanis N, Tzallas C, Siamopoulos K C
Department of Internal Medicine, School of Medicine, University of Ioannina, Greece.
Eur J Clin Invest. 1996 Oct;26(10):936-9. doi: 10.1111/j.1365-2362.1996.tb02141.x.
Immune system disturbances have been implicated in the pathogenesis of essential hypertension. The aim of this study was to determine the levels of the interleukin-1 beta and soluble interleukin-2 receptors in serum samples from 114 hypertensive patients before any drug therapy because there are no well-established data regarding these immunologic mediators in essential hypertension. We found increased levels of interleukin-1 beta in 59.6% of patients, while soluble interleukin-2 receptors were not detected. The interleukin-1 beta levels were significantly higher in patients than in healthy controls (P = 0.0001). We conclude that patients with essential hypertension have high levels of interleukin-1 beta but not indicators of cellular immune activation in their sera. Further studies are in progress in order to confirm, explain and assess the clinical utility of the above findings.
免疫系统紊乱被认为与原发性高血压的发病机制有关。本研究的目的是测定114例未经任何药物治疗的高血压患者血清样本中白细胞介素-1β和可溶性白细胞介素-2受体的水平，因为在原发性高血压中，关于这些免疫介质尚无确凿的数据。我们发现59.6%的患者白细胞介素-1β水平升高，而未检测到可溶性白细胞介素-2受体。患者的白细胞介素-1β水平显著高于健康对照组（P = 0.0001）。我们得出结论，原发性高血压患者血清中白细胞介素-1β水平较高，但无细胞免疫激活指标。为了证实、解释和评估上述发现的临床实用性，进一步的研究正在进行中。
