Herrera-Goepfert R, Garcia-Marcano R, Zeichner-Gancz I
Department of Pathology, Instituto Nacional de Cancerologia, Mexico City.
Rev Invest Clin. 1996 Jul-Aug;48(4):261-5.
We reviewed our cases of gastric MALT-lymphomas over a 12-year period at a national oncological referral center, the Instituto Nacional de Cancerología in Mexico City, looking for morphological evidence of Helicobacter pylori infection near the primary neoplasia. H pylori as well as lymphoid follicles and chronic active gastritis were carefully searched for in the adjacent mucosa. There were 23 (85%) low-grade and four (15%) high-grade MALT-lymphomas. H pylori microorganisms were found adjacent to the neoplasia in 23 cases (85%; CI 95% = 72-99%) but the lymphoid follicles were seen in 15 of 23 (65%; CI = 56-74%). Chronic active gastritis was present in 25 cases (93%; Cl = 90-95%). There was a close association between H pylori and gastric MALT-lymphoma. Lymphoid follicles were a reliable indicator of infection and the claimed pathophysiological substrate for MALT-lymphoma. We conclude that patients in whom gastric lymphoid follicles are detected, must remain under clinical follow-up since H pylori is a plausible promoter of neoplastic transformation.
我们回顾了墨西哥城国家肿瘤转诊中心——国家癌症研究所12年间的胃黏膜相关淋巴组织淋巴瘤病例，寻找原发性肿瘤附近幽门螺杆菌感染的形态学证据。在相邻黏膜中仔细查找幽门螺杆菌以及淋巴滤泡和慢性活动性胃炎。共有23例（85%）低级别和4例（15%）高级别黏膜相关淋巴组织淋巴瘤。23例（85%；95%置信区间=72-99%）肿瘤附近发现幽门螺杆菌微生物，但23例中有15例（65%；置信区间=56-74%）可见淋巴滤泡。25例（93%；置信区间=90-95%）存在慢性活动性胃炎。幽门螺杆菌与胃黏膜相关淋巴组织淋巴瘤之间存在密切关联。淋巴滤泡是感染的可靠指标，也是黏膜相关淋巴组织淋巴瘤所谓病理生理基础。我们得出结论，检测到胃淋巴滤泡的患者必须接受临床随访，因为幽门螺杆菌是肿瘤转化的一个合理促进因素。
