Aaby P, Samb B, Simondon F, Knudsen K, Seck A M, Bennett J, Markowitz L, Whittle H
UR Maladies Infectieuses et Parasitaires, ORSTOM, Dakar, Senegal.
Vaccine. 1996 Feb;14(3):226-9. doi: 10.1016/0264-410x(95)00178-4.
At 3-5 years of age, female recipients of Edmonston-Zagreb high-titre (EZ-HT) and Schwarz high-titre (SW-HT) measles vaccine had lower survival rates than female recipients of Schwarz standard measles vaccine (SW-STD) in Guinea-Bissau, Senegal and Haiti. In Senegal, the children who received high-titre vaccines have now been followed to the age of 5-7 years to determine whether the difference in mortality persisted, and whether differences in vaccine efficacy were apparent. At this age there was no difference in mortality between female recipients of high-titre and standard titre measles vaccines. There was no indication that high-titre EZ-HT vaccine at 5 months (EZ-HT,5m) provided suboptimal protection, as vaccine efficacy after exposure was 97% and 95%, respectively, for EZ-HT,5m and SW-STD,10m vaccines, whereas SW-HT,5m vaccine had an efficacy of 81%. The difference in mortality between recipients of high-titre vaccines and SW-STD observed in several studies during the first few years after vaccination may be explained by non-specific beneficial effects of the standard measles vaccine rather than a harmful effect of the high-titre vaccines.
在几内亚比绍、塞内加尔和海地，3至5岁的女性接种埃德蒙斯顿-萨格勒布高滴度（EZ-HT）和施瓦茨高滴度（SW-HT）麻疹疫苗后的存活率低于接种施瓦茨标准麻疹疫苗（SW-STD）的女性。在塞内加尔，接受高滴度疫苗的儿童现已随访至5至7岁，以确定死亡率差异是否持续存在，以及疫苗效力差异是否明显。在这个年龄段，高滴度和标准滴度麻疹疫苗的女性接种者的死亡率没有差异。没有迹象表明5个月时接种的高滴度EZ-HT疫苗（EZ-HT,5m）提供的保护不理想，因为暴露后的疫苗效力对于EZ-HT,5m和SW-STD,10m疫苗分别为97%和95%，而SW-HT,5m疫苗的效力为81%。在接种疫苗后的头几年，多项研究中观察到的高滴度疫苗接种者与SW-STD接种者之间的死亡率差异，可能是由标准麻疹疫苗的非特异性有益作用而非高滴度疫苗的有害作用所解释。
