Fairbanks V F, Klee G G, Wiseman G A, Hoyer J D, Tefferi A, Petitt R M, Silverstein M N
Department of Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Blood Cells Mol Dis. 1996;22(2):169-86; discussion 186a-186g. doi: 10.1006/bcmd.1996.0024.
Comparison of results of red cell mass (RCM) measurement by 51Cr and 125I methods in 119 patients showed virtual equivalence. Both methods have an acceptable coefficient of variation (CV) that is < 5%. The 125I method is simpler and much less expensive. Unrealistically narrow "normal ranges" for RCM are likely to lead to misdiagnosis of polycythemia vera. Upper normal limits of 39 mL/kg (males) and 32 mL/kg (females) are consistent with originally published data in normal persons; use of these limits as criteria would reduce the risk of misdiagnosis. No cases of "stress erythrocytosis" or Gaisbock Syndrome were encountered among the 119 cases reviewed.
对119例患者采用51Cr法和125I法测量红细胞容量（RCM）的结果进行比较，显示二者实际等效。两种方法都有可接受的变异系数（CV），即<5%。125I法更简单且成本低得多。RCM不切实际的狭窄“正常范围”可能导致真性红细胞增多症的误诊。男性39 mL/kg、女性32 mL/kg的正常上限与正常人群最初发表的数据一致；将这些限值用作标准将降低误诊风险。在审查的119例病例中未遇到“应激性红细胞增多症”或盖斯伯克综合征病例。
