Cull A, Hay C, Love S B, Mackie M, Smets E, Stewart M
Imperial Cancer Research Fund, Medical Oncology Unit, Western General Hospital, Edinburgh, UK.
Br J Cancer. 1996 Nov;74(10):1674-9. doi: 10.1038/bjc.1996.608.
Cognitive function items are increasingly included in quality of life measures, and complaints of concentration and memory difficulties are often reported by cancer patients. The aim of this study was to examine the factors influencing patients' level of complaint by comparing subjective reports with objective test performance of a sample of adult lymphoma patients, disease-free and > or = 6 months after treatment. There was no significant difference between complainers and non-complainers in sociodemographic or clinical characteristics or in their performance on standard neuropsychometric tests of concentration and memory. Those reporting concentration and memory difficulties had significantly higher scores on measures of anxiety, depression and fatigue. This calls into question the validity of including cognitive function items in self-report quality of life measures. Patients who report concentration and memory difficulties should be screened for clinically significant and potentially remediable mood disorder. Objective testing remains the method of choice for assessing higher mental function.
认知功能项目越来越多地被纳入生活质量测量中,癌症患者经常报告注意力不集中和记忆困难的问题。本研究的目的是通过比较一组成年淋巴瘤患者的主观报告与客观测试表现,来检查影响患者抱怨程度的因素,这些患者处于无病状态且治疗后≥6个月。在社会人口统计学或临床特征方面,以及在注意力和记忆的标准神经心理测试表现上,抱怨者和非抱怨者之间没有显著差异。那些报告有注意力和记忆困难的患者在焦虑、抑郁和疲劳测量方面得分显著更高。这对将认知功能项目纳入自我报告的生活质量测量的有效性提出了质疑。报告有注意力和记忆困难的患者应接受临床上显著且可能可治疗的情绪障碍筛查。客观测试仍然是评估高级心理功能的首选方法。