Blachere N E, Srivastava P K
Department of Biological Sciences, Fordham University, Bronx, NY 10458, USA.
Semin Cancer Biol. 1995 Dec;6(6):349-55. doi: 10.1016/1044-579x(95)90004-7.
Heat shock proteins (HSPs) are associated in vivo with the entire repertoire of peptides (antigenic and otherwise) generated within that cell. Immunization with such non-covalent HSP-peptide complexes is unusually efficient in eliciting cellular immune responses against the antigenic peptides associated with the HSPs. This broad and general principle is the basis for a new generation of vaccines against cancers and infectious diseases and circumvents the need for identification of the T-cell epitopes for any given cancer or infectious agent.
