肺炎患儿肺组织中人疱疹病毒6型的流行情况。

Prevalence of human herpesvirus 6 in lung tissue from children with pneumonitis.

作者信息

Hammerling J A, Lambrecht R S, Kehl K S, Carrigan D R

机构信息

Department of Pathology, Children's Hospital of Wisconsin, Milwaukee 53201, USA.

出版信息

J Clin Pathol. 1996 Oct;49(10):802-4. doi: 10.1136/jcp.49.10.802.

DOI:10.1136/jcp.49.10.802

PMID:8943744

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC500772/

Abstract

AIMS/BACKGROUND: Human herpesvirus type 6 (HHV-6) is the aetiological agent of exanthem subitum, and has also been linked with a variety of other diseases. The aim of this study was to investigate the role of HHV-6 in pneumonitis in children.

METHODS

Formalin fixed, paraffin wax embedded lung tissue from 33 children (age range two months to 16 years) who died with pneumonitis was subjected to immunohistochemical staining for HHV-6 using an avidin-biotin method.

RESULTS

Active HHV-6 infection was demonstrated in four children: a bone marrow transplant recipient with concomitant adenovirus infection, a patient with hepatitis of unknown aetiology, a patient with congenital anomalies, and a patient with congenital immunodeficiency.

CONCLUSION

Accurate localisation of HHV-6 is possible in postmortem lung tissue. HHV-6 either alone or in combination with other pathogens may play a role in the development of pneumonitis.

摘要

目的/背景：人疱疹病毒6型（HHV - 6）是幼儿急疹的病原体，也与多种其他疾病有关。本研究的目的是调查HHV - 6在儿童肺炎中的作用。