大鼠寒颤产热和非寒颤产热的控制
The control of shivering and non-shivering thermogenesis in the rat.
作者信息
Banet M, Hensel H
出版信息
J Physiol. 1977 Aug;269(3):669-76. doi: 10.1113/jphysiol.1977.sp011921.
Abstract
- The effect of intraperitoneal administration of propranolol (4, 8 and 12 mg/kg) on colonic temperature was studied in twelve rats during exposure to ambient temperatures of 30, 15 and 5 degrees C. 2. At 30 degrees C, propranolol had no effect on colonic temperature; at 15 and 5 degrees C, however, 4 mg propanolol/kg induced a fall in colonic temperature of about 0-8 degrees C, whereas 8 and 12 mg propanolol/kg induced a fall of about 1-5-2-0 degrees C. 3. Assuming that the temperature regulations system of the rat has a proportional controller and that the effect of propranolol was due to the blockade of non-shivering thermogenesis, the results are interpreted as showing that shivering is activated only when heat loss exceeds the capacity for non-shivering thermogenesis.
摘要
- 在12只大鼠暴露于30℃、15℃和5℃环境温度期间，研究了腹腔注射普萘洛尔（4、8和12毫克/千克）对结肠温度的影响。2. 在30℃时，普萘洛尔对结肠温度无影响；然而，在15℃和5℃时，4毫克普萘洛尔/千克可使结肠温度下降约0 - 8℃，而8和12毫克普萘洛尔/千克可使结肠温度下降约1 - 5 - 2 - 0℃。3. 假设大鼠的体温调节系统有一个比例控制器，且普萘洛尔的作用是由于阻断了非寒战产热，那么这些结果被解释为表明只有当热损失超过非寒战产热能力时，寒战才会被激活。
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