来自桃金娘叶叶下珠的六种木脂素。

Six lignans from Phyllanthus myrtifolius.

作者信息

Lee S S, Lin M T, Liu C L, Lin Y Y, Liu K C

机构信息

School of Pharmacy, National Taiwan University, Taipei, Republic of China.

出版信息

J Nat Prod. 1996 Nov;59(11):1061-5. doi: 10.1021/np960322+.

DOI:10.1021/np960322+

PMID:8946748

Abstract

Six lignans comprising phyllamyricins D (1), E (2), and F (3) and phyllamyricosides A (4), B (5), and C (6) were isolated in a continuing study of Phyllanthus myrtifolius. Compounds 1 and 2 are 2a-methoxy-4-aryl-2,3-naphthalides. Compounds 3-6 belong to the 4-arylnaphthalene class, with compounds 4-6 being O-beta-glucosides. Their structures were elucidated on the basis of spectral analysis. Compound 4 increased the activity of HIV-1 reverse transcriptase by 65% at a concentration of 1.89 microM.

摘要

在对小叶叶下珠（Phyllanthus myrtifolius）的持续研究中，分离出了六种木脂素，包括叶下珠霉素D（1）、E（2）和F（3）以及叶下珠苷A（4）、B（5）和C（6）。化合物1和2是2a-甲氧基-4-芳基-2,3-萘二甲酸酯。化合物3至6属于4-芳基萘类，化合物4至6为O-β-葡萄糖苷。通过光谱分析阐明了它们的结构。化合物4在浓度为1.89 microM时可使HIV-1逆转录酶的活性提高65%。