Epstein J H, Grekin D A
J Invest Dermatol. 1981 Mar;76(3):178-80. doi: 10.1111/1523-1747.ep12525686.
The effects of all-trans retinoic acid (RA) in 0.05%, 0.025% and 0.005% concentrations on ultraviolet (UV) induced carcinogenesis was investigated in the skin of Uscd strain hairless mice. A carcinogenic amount of UV energy was delivered over the 12-mo period of the study. The 0.025% and 0.005% RA solutions did not alter the development of cutaneous cancers. However, the 0.05% RA concentration significantly inhibited the tumor formation in this study.
研究了浓度为0.05%、0.025%和0.005%的全反式维甲酸（RA）对Uscd品系无毛小鼠皮肤紫外线（UV）诱导致癌作用的影响。在为期12个月的研究期间，给予致癌剂量的紫外线能量。0.025%和0.005%的RA溶液并未改变皮肤癌的发展。然而，在本研究中，0.05%的RA浓度显著抑制了肿瘤形成。
