Wiig M, Hanff G, Abrahamsson S O, Lohmander L S
Department of Hand Surgery, University Hospital in Malmo, Sweden.
Acta Orthop Scand. 1996 Oct;67(5):491-7. doi: 10.3109/17453679608996675.
Deep flexor tendons of 30 rabbits were divided at the ankle level. The effects of unloading on the synthesis and content of matrix components, the synthesis of DNA, and dry weight were investigated. The ability of the tendons to synthesize collagen during short-term culture and the contents of matrix components decreased inversely to the time of unloading. 12 weeks following division, the fibrocartilagnious segments had lost 2/5 of their dry weight, 2/3 of proteoglycan and 1/3 of collagen and non-collagen protein content. Less pronounced losses were observed in the non-fibrocartilaginous segments. A transient increase in cell proliferation in both types of segments was found. These findings indicate that divided flexor tendons undergo a progressive degradation, degradation, which may have implications for delayed suture of deep flexor tendon injuries.
将30只兔子的趾深屈肌腱在踝关节水平切断。研究了负荷解除对基质成分的合成与含量、DNA合成以及干重的影响。肌腱在短期培养期间合成胶原蛋白的能力以及基质成分的含量与负荷解除时间呈反比下降。切断后12周，纤维软骨段失去了其2/5的干重、2/3的蛋白聚糖以及1/3的胶原蛋白和非胶原蛋白含量。在非纤维软骨段观察到的损失不太明显。在两种类型的节段中均发现细胞增殖有短暂增加。这些发现表明，切断的屈肌腱会逐渐退化，这可能对趾深屈肌腱损伤的延迟缝合有影响。
