François G, Aké Assi L, Holenz J, Bringmann G
Prins Leopold Instituut voor Tropische Geneeskunde, Antwerpen, Belgium.
J Ethnopharmacol. 1996 Nov;54(2-3):113-7. doi: 10.1016/s0378-8741(96)01456-0.
The antiplasmodial activities of organic and aqueous extracts from the West African plant Picralima nitida (Apocynaceae) were examined in an in vitro model, against asexual erythrocytic forms of Plasmodium falciparum. Root and leaf extracts of this species had never been examined before. Several extracts displayed considerable inhibitory activities. The highest activities were found in root, stem bark and fruit rind extracts, with IC50 values of 0.188, 0.545 and 1.581 micrograms/ml, respectively. The leaf and seed extracts generally yielded much lower activity or were completely inactive.
在体外模型中检测了西非植物 Picralima nitida（夹竹桃科）的有机提取物和水提取物对恶性疟原虫无性红细胞形式的抗疟活性。此前从未对该物种的根和叶提取物进行过检测。几种提取物表现出相当大的抑制活性。在根、茎皮和果皮提取物中发现了最高活性，IC50 值分别为 0.188、0.545 和 1.581 微克/毫升。叶和种子提取物通常活性低得多或完全无活性。
