FtsA以FtsZ依赖的方式定位于隔膜。
FtsA is localized to the septum in an FtsZ-dependent manner.
作者信息
Addinall S G, Lutkenhaus J
机构信息
Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City 66160, USA.
出版信息
J Bacteriol. 1996 Dec;178(24):7167-72. doi: 10.1128/jb.178.24.7167-7172.1996.
Abstract
The localization of the cell division protein FtsA in E. coli was examined. FtsA was found to localize to the septum in a ring pattern as previously shown for FtsZ. The localization of FtsA was completely dependent on the localization of FtsZ. Under a variety of conditions that prevented formation of the Z ring, FtsA was unable to localize. In mutants where FtsZ forms structures in addition to Z rings, the pattern of FtsA duplicated these structures. These results suggest that the Z ring recruits FtsA to the septum.
摘要
对大肠杆菌中细胞分裂蛋白FtsA的定位进行了检测。结果发现，FtsA以环状模式定位于隔膜，正如之前对FtsZ所显示的那样。FtsA的定位完全依赖于FtsZ的定位。在多种阻止Z环形成的条件下，FtsA无法定位。在FtsZ除形成Z环外还形成其他结构的突变体中，FtsA的模式复制了这些结构。这些结果表明，Z环将FtsA招募到隔膜处。
相似文献
1
FtsA is localized to the septum in an FtsZ-dependent manner.FtsA以FtsZ依赖的方式定位于隔膜。
J Bacteriol. 1996 Dec;178(24):7167-72. doi: 10.1128/jb.178.24.7167-7172.1996.
2
Colocalization of cell division proteins FtsZ and FtsA to cytoskeletal structures in living Escherichia coli cells by using green fluorescent protein.利用绿色荧光蛋白研究细胞分裂蛋白FtsZ和FtsA在活的大肠杆菌细胞中与细胞骨架结构的共定位。
Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12998-3003. doi: 10.1073/pnas.93.23.12998.
3
The proper ratio of FtsZ to FtsA is required for cell division to occur in Escherichia coli.在大肠杆菌中，细胞分裂的发生需要FtsZ与FtsA的适当比例。
J Bacteriol. 1992 Oct;174(19):6145-51. doi: 10.1128/jb.174.19.6145-6151.1992.
4
FtsN, a late recruit to the septum in Escherichia coli.FtsN，一种在大肠杆菌中较晚定位于隔膜的蛋白。
Mol Microbiol. 1997 Jul;25(2):303-9. doi: 10.1046/j.1365-2958.1997.4641833.x.
5
Recruitment of ZipA to the septal ring of Escherichia coli is dependent on FtsZ and independent of FtsA.ZipA募集到大肠杆菌的隔膜环上依赖于FtsZ且不依赖于FtsA。
J Bacteriol. 1999 Jan;181(1):167-76. doi: 10.1128/JB.181.1.167-176.1999.
6
Cell division inhibitors SulA and MinC/MinD block septum formation at different steps in the assembly of the Escherichia coli division machinery.细胞分裂抑制剂SulA和MinC/MinD在大肠杆菌分裂机制组装的不同步骤中阻止隔膜形成。
Mol Microbiol. 2000 Jul;37(2):410-23. doi: 10.1046/j.1365-2958.2000.02007.x.
7
Interactions between heterologous FtsA and FtsZ proteins at the FtsZ ring.在FtsZ环处异源FtsA和FtsZ蛋白之间的相互作用。
J Bacteriol. 1997 Nov;179(21):6788-97. doi: 10.1128/jb.179.21.6788-6797.1997.
8
A specific role for the ZipA protein in cell division: stabilization of the FtsZ protein.ZipA 蛋白在细胞分裂中的特定作用：稳定 FtsZ 蛋白。
J Biol Chem. 2013 Feb 1;288(5):3219-26. doi: 10.1074/jbc.M112.434944. Epub 2012 Dec 11.
9
FtsEX acts on FtsA to regulate divisome assembly and activity.FtsEX作用于FtsA以调节分裂体的组装和活性。
Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E5052-61. doi: 10.1073/pnas.1606656113. Epub 2016 Aug 8.
10
A mutation in Escherichia coli ftsZ bypasses the requirement for the essential division gene zipA and confers resistance to FtsZ assembly inhibitors by stabilizing protofilament bundling.大肠杆菌ftsZ基因的一个突变绕过了对必需分裂基因zipA的需求，并通过稳定原丝束化赋予对FtsZ组装抑制剂的抗性。
Mol Microbiol. 2015 Sep;97(5):988-1005. doi: 10.1111/mmi.13081. Epub 2015 Jul 4.
引用本文的文献
1
Crosslinking by ZapD drives the assembly of short FtsZ filaments into toroidal structures in solution.由ZapD介导的交联作用促使溶液中的短FtsZ细丝组装成环形结构。
Elife. 2025 Sep 15;13:RP95557. doi: 10.7554/eLife.95557.
2
Cell division protein CdpA organises and anchors the midcell ring in haloarchaea.细胞分裂蛋白CdpA在嗜盐古菌中组织并锚定细胞中部环。
Nat Commun. 2025 May 31;16(1):5076. doi: 10.1038/s41467-025-60079-8.
3
Actin network evolution as a key driver of eukaryotic diversification.肌动蛋白网络进化作为真核生物多样化的关键驱动力。
J Cell Sci. 2024 Aug 1;137(15). doi: 10.1242/jcs.261660. Epub 2024 Aug 9.
4
Comparative genomics hints at dispensability of multiple essential genes in two Escherichia coli L-form strains.比较基因组学提示在两种大肠杆菌 L 型菌株中有多个必需基因的非必需性。
Biosci Rep. 2023 Oct 31;43(10). doi: 10.1042/BSR20231227.
5
Light-dependent signal transduction in the marine diatom .海洋硅藻中的光依赖性信号转导
Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2216286120. doi: 10.1073/pnas.2216286120. Epub 2023 Mar 10.
6
In vitro assembly, positioning and contraction of a division ring in minimal cells.在最小细胞中进行分裂环的体外组装、定位和收缩。
Nat Commun. 2022 Oct 15;13(1):6098. doi: 10.1038/s41467-022-33679-x.
7
Assembly dynamics of FtsZ and DamX during infection-related filamentation and division in uropathogenic E. coli.尿路致病性大肠杆菌感染相关丝状体形成和分裂过程中 FtsZ 和 DamX 的组装动力学。
Nat Commun. 2022 Jun 25;13(1):3648. doi: 10.1038/s41467-022-31378-1.
8
In vitro reconstitution of Escherichia coli divisome activation.体外重建大肠杆菌分裂体的激活。
Nat Commun. 2022 May 12;13(1):2635. doi: 10.1038/s41467-022-30301-y.
9
Discovery of FtsZ inhibitors by virtual screening as antibacterial agents and study of the inhibition mechanism.通过虚拟筛选发现作为抗菌剂的FtsZ抑制剂及其抑制机制的研究。
RSC Med Chem. 2021 Nov 15;13(1):79-89. doi: 10.1039/d1md00249j. eCollection 2022 Jan 27.
10
Functions of the Essential Gene in Cellular Morphogenesis and Development of the Filamentous Cyanobacterium PCC 7120.必需基因在丝状蓝细菌集胞藻PCC 7120细胞形态发生和发育中的功能
Front Microbiol. 2021 Oct 21;12:765878. doi: 10.3389/fmicb.2021.765878. eCollection 2021.
本文引用的文献
1
FtsZ-spirals and -arcs determine the shape of the invaginating septa in some mutants of Escherichia coli.FtsZ螺旋和弧形结构决定了大肠杆菌某些突变体中内陷隔膜的形状。
Mol Microbiol. 1996 Oct;22(2):231-7. doi: 10.1046/j.1365-2958.1996.00100.x.
2
Interaction between FtsZ and inhibitors of cell division.FtsZ与细胞分裂抑制剂之间的相互作用。
J Bacteriol. 1996 Sep;178(17):5080-5. doi: 10.1128/jb.178.17.5080-5085.1996.
3
FtsZ ring formation in fts mutants.fts突变体中的FtsZ环形成。
J Bacteriol. 1996 Jul;178(13):3877-84. doi: 10.1128/jb.178.13.3877-3884.1996.
4
Transcription factor Spo0A switches the localization of the cell division protein FtsZ from a medial to a bipolar pattern in Bacillus subtilis.转录因子Spo0A可使枯草芽孢杆菌中细胞分裂蛋白FtsZ的定位模式从中间型转变为双极型。
Genes Dev. 1996 Feb 15;10(4):478-88. doi: 10.1101/gad.10.4.478.
5
Bacterial cell division protein FtsZ assembles into protofilament sheets and minirings, structural homologs of tubulin polymers.细菌细胞分裂蛋白FtsZ组装成原丝片层和微环，它们是微管蛋白聚合物的结构同源物。
Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):519-23. doi: 10.1073/pnas.93.1.519.
6
Cloning and characterization of ftsN, an essential cell division gene in Escherichia coli isolated as a multicopy suppressor of ftsA12(Ts).大肠杆菌中作为ftsA12（Ts）多拷贝抑制子分离得到的必需细胞分裂基因ftsN的克隆与特性分析
J Bacteriol. 1993 Jun;175(12):3790-7. doi: 10.1128/jb.175.12.3790-3797.1993.
7
Cell division inhibitors SulA and MinCD prevent formation of the FtsZ ring.细胞分裂抑制剂SulA和MinCD可阻止FtsZ环的形成。
J Bacteriol. 1993 Feb;175(4):1118-25. doi: 10.1128/jb.175.4.1118-1125.1993.
8
FtsZ ring in bacterial cytokinesis.细菌胞质分裂中的FtsZ环。
Mol Microbiol. 1993 Aug;9(3):403-9. doi: 10.1111/j.1365-2958.1993.tb01701.x.
9
The cell cycle of Escherichia coli.大肠杆菌的细胞周期。
Annu Rev Microbiol. 1993;47:199-230. doi: 10.1146/annurev.mi.47.100193.001215.
10
Guanine nucleotide-dependent assembly of FtsZ into filaments.鸟嘌呤核苷酸依赖性FtsZ组装成丝状体。
J Bacteriol. 1994 May;176(9):2754-8. doi: 10.1128/jb.176.9.2754-2758.1994.
Zotero 插件