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脑膜炎球菌病中的促炎和抗炎细胞因子。

Proinflammatory and anti-inflammatory cytokines in meningococcal disease.

作者信息

Riordan F A, Marzouk O, Thomson A P, Sills J A, Hart C A

机构信息

Institute of Child Health, University of Liverpool.

出版信息

Arch Dis Child. 1996 Nov;75(5):453-4. doi: 10.1136/adc.75.5.453.

DOI:10.1136/adc.75.5.453
PMID:8957964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1511765/
Abstract

Interleukin-10 (IL-10), an anti-inflammatory cytokine, was measured in 131 children with meningococcal disease. IL-10 concentrations were significantly higher in children who died and correlated positively with proinflammatory cytokines. Children who die from meningococcal disease have high IL-10 concentrations, which do not suppress proinflammatory cytokines.

摘要

在131例患脑膜炎球菌病的儿童中检测了抗炎细胞因子白细胞介素-10（IL-10）。死亡儿童的IL-10浓度显著更高，且与促炎细胞因子呈正相关。死于脑膜炎球菌病的儿童IL-10浓度很高，但其并未抑制促炎细胞因子。

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本文引用的文献

1
High levels of interleukin-10 during the initial phase of fulminant meningococcal septic shock.暴发性脑膜炎球菌性败血症休克初始阶段白细胞介素-10水平升高。
J Infect Dis. 1995 Jan;171(1):229-32. doi: 10.1093/infdis/171.1.229.
2
High levels of interleukin 10 in serum are associated with fatality in meningococcal disease.血清中白细胞介素10水平升高与脑膜炎球菌病的死亡率相关。
Infect Immun. 1995 Jun;63(6):2109-12. doi: 10.1128/iai.63.6.2109-2112.1995.
3
Correlation between proinflammatory cytokines and antiinflammatory mediators and the severity of disease in meningococcal infections.促炎细胞因子与抗炎介质之间的相关性以及脑膜炎球菌感染中疾病的严重程度。
J Infect Dis. 1995 Aug;172(2):433-9. doi: 10.1093/infdis/172.2.433.
4
The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome.脑膜炎球菌性感染性休克患者血清中细胞因子的复杂模式。白细胞介素6、白细胞介素1与致命结局之间的关联。
J Exp Med. 1989 Jan 1;169(1):333-8. doi: 10.1084/jem.169.1.333.