McCahy P J, Harris C A, Neal D E
Department of Surgery, University of Newcastle upon Tyne, UK.
Br J Urol. 1996 Oct;78(4):552-6. doi: 10.1046/j.1464-410x.1996.17111.x.
To assess the risk of breast, ovarian and prostate cancer in the families of men with prostate cancer.
A case-control study was performed by interviewing patients with prostate cancer and obtaining detailed information on family histories of cancer. Controls were hospital-based patients, of a similar age to the cases, with bladder cancer or benign prostatic hypertrophy.
A total of 209 cases and 322 controls were interviewed; of the cases, 22.5% had family members with a history of one or more of breast, ovarian or prostate cancers, compared with 15.2% of controls (P < 0.05). The odds ratio (OR) of having prostate cancer when there was a positive family history was 8.22 and the OR of a female relative of a patient with prostate cancer having breast cancer was 1.51. There was no apparent increased risk of ovarian or any other cancer.
We confirm previous reports of an increased incidence of prostate cancer in the families of men with prostate cancer and report a similarly increased incidence of breast cancer in female relatives. We suggest that detailed family histories be taken routinely and intend to analyse blood samples provided from this study for genetic abnormalities.
评估前列腺癌男性患者家族中患乳腺癌、卵巢癌和前列腺癌的风险。
通过对前列腺癌患者进行访谈并获取癌症家族史的详细信息，开展了一项病例对照研究。对照为年龄与病例相似的、患有膀胱癌或良性前列腺增生的住院患者。
共访谈了209例病例和322例对照；病例中有22.5%的家庭成员有乳腺癌、卵巢癌或前列腺癌中的一种或多种癌症病史，而对照中这一比例为15.2%（P<0.05）。家族史呈阳性时患前列腺癌的比值比（OR）为8.22，前列腺癌患者的女性亲属患乳腺癌的OR为1.51。卵巢癌或任何其他癌症的风险无明显增加。
我们证实了先前关于前列腺癌男性患者家族中前列腺癌发病率增加的报道，并报告了女性亲属中乳腺癌发病率也有类似增加。我们建议常规采集详细的家族史，并打算分析本研究提供的血样以检测基因异常。
