Lips P, Agnusdei D, Caulin F, Cooper C, Johnell O, Kanis J, Liberman U, Minne H, Reeve J, Reginster J Y, de Vernejoul M C, Wiklund I
Department of Endocrinology, Free University Hospital, Amsterdam, The Netherlands.
Scand J Rheumatol Suppl. 1996;103:84-5; discussion 86-8. doi: 10.3109/03009749609103757.
The complaints of vertebral osteoporosis usually result from wedge or crush fractures and biconcave deformities. These are caused by a decrease of bone mass and deterioration of bone structure leading to loss of strength. Treatment of osteoporosis should result in an increase of bone mass, and the incidence of new vertebral fractures should diminish. However, new vertebral fractures are not always accompanied by pain, and disability does not well correlate with the number of vertebral fractures. Patients with osteoporosis often have other problems e.g. with taking a shower, preparing meals, gardening, walking stairs, visiting friends and attending social activities. In addition, pain and disability may influence mood and lead to depression. The assessment of quality of life should be a primary endpoint in clinical trials in patients with osteoporosis and in individual patients care. Recently, the European Foundation for Osteoporosis (EFFO) has decided a develop a questionnaire for patients with vertebral osteoporosis, i.e. patients with vertebral deformities. The questionnaire is meant for use in clinical trials. A questionnaire was made including 48 questions and 6 visual analogue scales. The questions concern the following domains: pain, activities of daily living, jobs around the house, moving, leisure and social activities, general health perception and mood. The questionnaire ("Qualeffo") has now entered the validation phase. The first study in 8 centres concerns the within-subject reproducibility, the internal coherence, and the specificity by comparing osteoporotic patients with a control group not suffering from osteoporosis or backpain.
椎体骨质疏松症的症状通常源于楔形或压缩性骨折以及双凹畸形。这些是由骨量减少和骨结构退化导致强度丧失引起的。骨质疏松症的治疗应能增加骨量，并减少新椎体骨折的发生率。然而，新椎体骨折并不总是伴有疼痛，残疾程度与椎体骨折的数量也没有很好的相关性。骨质疏松症患者往往还有其他问题，例如洗澡、做饭、园艺、爬楼梯、拜访朋友和参加社交活动等方面。此外，疼痛和残疾可能会影响情绪并导致抑郁。生活质量评估应成为骨质疏松症患者临床试验和个体患者护理的主要终点。最近，欧洲骨质疏松症基金会（EFFO）决定为椎体骨质疏松症患者，即椎体畸形患者开发一份问卷。该问卷旨在用于临床试验。制作了一份包含48个问题和6个视觉模拟量表的问卷。这些问题涉及以下领域：疼痛、日常生活活动、家务、移动、休闲和社交活动、总体健康感知和情绪。该问卷（“Qualeffo”）现已进入验证阶段。在8个中心进行的第一项研究通过将骨质疏松症患者与未患骨质疏松症或背痛的对照组进行比较，关注受试者内部的可重复性、内部一致性和特异性。
