Plyusnin A, Cheng Y, Lehväslaiho H, Vaheri A
Haartman Institute, Department of Virology, University of Helsinki, Finland.
J Virol. 1996 Dec;70(12):9060-3. doi: 10.1128/JVI.70.12.9060-9063.1996.
Tula virus (TUL) is a recently detected hantavirus carried by European common voles. Reverse transcriptase PCR cloning was used to study TUL S segment/N protein quasispecies. Both the distribution and character of mutations observed in three mutant spectra indicated limited selection at the protein level. At least 8% of the mutations were neutral or well tolerated; fixation of such mutations may play a role in TUL evolution in its natural host.
土拉病毒（TUL）是一种最近发现的由欧洲普通田鼠携带的汉坦病毒。采用逆转录酶PCR克隆技术研究土拉病毒S片段/N蛋白准种。在三个突变谱中观察到的突变分布和特征均表明在蛋白质水平上选择有限。至少8%的突变是中性的或耐受性良好的；这些突变的固定可能在土拉病毒在其自然宿主中的进化中起作用。
