Sykes A J, Allan E, Irwin C
Christie Hospital, Manchester, UK.
Clin Oncol (R Coll Radiol). 1996;8(6):384-6. doi: 10.1016/s0936-6555(96)80086-0.
After skin cancer, squamous cell carcinoma (SCC) of the lip is the most common cancer of the head and neck. It can be treated in a variety of ways, including both surgery and radiotherapy. Many centres have reported excellent cure and local control rates for their chosen treatment method. Electron beam treatment is recognized as a method of treatment and has theoretical advantages related to its depth-dose characteristics. We report a retrospective study of the treatment with electrons of 26 patients with Stage T1-2 SCCs of the lip. With a median follow-up period of 31 months (range 1.5-60) 100% local control was obtained, although two patients required surgical salvage, one for a geographical miss. One patient presented with metastatic neck nodes, and one relapsed in the neck, but both were treated with a combination of surgery and radiotherapy and were free of disease at follow-up. Patients tolerated the acute radiation reaction well and the long term cosmetic and functional results were good. Two patients experienced minor soft tissue necrosis, one of whom required surgical treatment. Electron treatment for T1-2 SCC of the lip is an effective, well tolerated treatment for these patients, many of whom are elderly and frail.
唇鳞状细胞癌（SCC）是继皮肤癌之后头颈部最常见的癌症。其治疗方式多种多样，包括手术和放疗。许多中心都报告了其所选治疗方法出色的治愈率和局部控制率。电子束治疗被公认为一种治疗方法，且因其深度剂量特性具有理论优势。我们报告了一项对26例T1-2期唇部SCC患者进行电子束治疗的回顾性研究。中位随访期为31个月（范围1.5 - 60个月），尽管有2例患者需要手术补救，其中1例是因为照射野遗漏，但仍获得了100%的局部控制。1例患者出现颈部淋巴结转移，1例颈部复发，但二者均接受了手术和放疗联合治疗，随访时均无疾病。患者对急性放射反应耐受性良好，长期美容和功能效果良好。2例患者出现轻微软组织坏死，其中1例需要手术治疗。对于唇部T1-2期SCC患者，电子束治疗是一种有效且耐受性良好的治疗方法，这些患者中许多是老年体弱患者。
