Kaburaki J, Kuramochi S, Fujii T, Kuwana M, Tojo T, Ikeda Y, Hosada Y
Department of Internal Medicine, Keio University School of Medicine, Japan.
Clin Rheumatol. 1996 Nov;15(6):613-6. doi: 10.1007/BF02238554.
We report on a 33-year-old female patient with systemic sclerosis and nodular regenerative hyperplasia of the liver (NRHL). A needle biopsy of the patient's liver did not reveal the histology of NRHL or liver cirrhosis at her first visit to our hospital, when portal hypertension was demonstrated by percutaneous transhepatic portography. After 11 years, the patient died of hepatic and renal failure. At the time of autopsy, multiple nodules were found in the liver, and a microscopic examination showed a histology compatible with NRHL. It is suggested that the immunological disturbance was related to the patient's portal hypertension and NRHL.
我们报告了一名33岁患有系统性硬化症和肝脏结节性再生性增生（NRHL）的女性患者。该患者首次来我院就诊时，经皮肝穿门静脉造影显示存在门静脉高压，但肝脏穿刺活检未发现NRHL或肝硬化的组织学表现。11年后，患者死于肝肾功能衰竭。尸检时，在肝脏中发现多个结节，显微镜检查显示其组织学表现符合NRHL。提示免疫紊乱与患者的门静脉高压和NRHL有关。
