糖尿病眼病模拟以比较筛查策略。
Simulation of diabetic eye disease to compare screening policies.
作者信息
Davies R, Sullivan P, Canning C
机构信息
School of Management, University of Southampton.
出版信息
Br J Ophthalmol. 1996 Nov;80(11):945-50. doi: 10.1136/bjo.80.11.945.
AIMS/BACKGROUND: The purpose of the project was to develop a technique for evaluating screening policies in the treatment of insulin dependent diabetic retinopathy. The study was concerned with patients who contracted the disease, aged under 35 years. Simulation was used to describe the progress of a cohort of patients through disease and treatment.
METHOD
Data, derived from a literature survey of European and American population and clinic studies, were used to model as closely as possible the development of retinopathy in all its stages, together with the effects of screening and treatment. The model output was validated against published data.
RESULTS
The results showed that where screening sensitivities are high, the frequency of screening makes little difference to the years of sight saved, but it does make a difference if screening sensitivities are close to 50%.
CONCLUSIONS
Although annual screening is normally desirable, biannual screening could be considered where patient compliance and screening sensitivities are both high.
目的/背景：该项目的目的是开发一种评估胰岛素依赖型糖尿病视网膜病变治疗筛查策略的技术。该研究针对的是35岁以下患此病的患者。通过模拟描述一组患者在疾病和治疗过程中的进展情况。
方法
数据来源于对欧美人群和临床研究的文献调查，尽可能紧密地模拟视网膜病变各阶段的发展情况以及筛查和治疗的效果。模型输出结果与已发表的数据进行了验证。
结果
结果表明，在筛查敏感度较高的情况下，筛查频率对挽救视力的年限影响不大，但如果筛查敏感度接近50%，则会产生影响。
结论
虽然通常需要每年进行筛查，但在患者依从性和筛查敏感度都较高的情况下，可以考虑每半年进行一次筛查。
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