Tirosh E, Libon D, Bader D
Jacobo Lichtman Apnea Investigation Unit, Bnai Zion Medical Center, Haifa, Israel.
J Perinatol. 1996 Nov-Dec;16(6):435-8.
Ten term infants who were exposed to maternal smoking during pregnancy and 10 age- and sex-matched control infants participated in the study. At the age of 48 hours (+/- 10), all infants underwent a 150- to 200-minute polygraphic study in a soundproof laboratory. Respiratory and heart rates, distribution of sleep states, and oxygen saturation were comparable in the two groups. The number and length of apneic events were similarly distributed in the two groups. The proportion of obstructive apneic events followed by arousal was significantly higher in the control group especially during quiet sleep (p = 0.001). It appears that exposure to smoking during pregnancy is associated with a higher arousal threshold in term infants. This finding could be of relevance in the assessment of maternal smoking as a risk factor for sudden infant death syndrome.
10名在孕期暴露于母亲吸烟环境下的足月儿和10名年龄及性别匹配的对照足月儿参与了该研究。在48小时（±10小时）时，所有婴儿在隔音实验室接受了150至200分钟的多导睡眠图研究。两组婴儿的呼吸和心率、睡眠状态分布以及血氧饱和度相当。两组呼吸暂停事件的数量和时长分布相似。对照组中阻塞性呼吸暂停事件后伴有觉醒的比例显著更高，尤其是在安静睡眠期间（p = 0.001）。看来孕期暴露于吸烟环境与足月儿较高的觉醒阈值有关。这一发现可能与将母亲吸烟评估为婴儿猝死综合征的危险因素相关。
