拉沙洛西对鼠卡氏肺孢子虫肺炎的疗效。
Efficacy of lasalocid against murine Pneumocystis carinii pneumonitis.
作者信息
OZ H S, Hughes W T, Rehg J E
机构信息
Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis Tennessee 38105, USA.
出版信息
Antimicrob Agents Chemother. 1997 Jan;41(1):191-2. doi: 10.1128/AAC.41.1.191.
Abstract
The efficacy of the ionophore lasalocid against Pneumocystis carinii pneumonitis in corticosteroid-immunosuppressed Sprague-Dawley rats was investigated. Lasalocid was effective in the prevention of the pneumonitis in a dose-dependent manner. At dosages of 0, 5, 10, and 20 mg/kg/day, P. carinii infection rates were 92, 60, 20, and 0%, respectively, during dexamethasone immunosuppression. Also, lasalocid compared favorably with other drugs known to have anti-P. carinii activity, including trimethoprim-sulfamethoxazole, atovaquone, and dapsone-trimethoprim.
摘要
研究了离子载体拉沙洛西对皮质类固醇免疫抑制的斯普拉格-道利大鼠卡氏肺孢子虫肺炎的疗效。拉沙洛西以剂量依赖的方式有效预防肺炎。在0、5、10和20mg/kg/天的剂量下，地塞米松免疫抑制期间卡氏肺孢子虫的感染率分别为92%、60%、20%和0%。此外，拉沙洛西与已知具有抗卡氏肺孢子虫活性的其他药物相比，效果良好，这些药物包括甲氧苄啶-磺胺甲恶唑、阿托伐醌和氨苯砜-甲氧苄啶。
相似文献
1
Efficacy of lasalocid against murine Pneumocystis carinii pneumonitis.拉沙洛西对鼠卡氏肺孢子虫肺炎的疗效。
Antimicrob Agents Chemother. 1997 Jan;41(1):191-2. doi: 10.1128/AAC.41.1.191.
2
Successful treatment and prevention of murine Pneumocystis carinii pneumonitis with 4,4'-sulfonylbisformanilide.用4,4'-磺酰双甲酰苯胺成功治疗和预防小鼠卡氏肺孢子虫肺炎。
Antimicrob Agents Chemother. 1986 Mar;29(3):509-10. doi: 10.1128/AAC.29.3.509.
3
Monodrug efficacies of sulfonamides in prophylaxis for Pneumocystis carinii pneumonia.磺胺类药物预防卡氏肺孢子虫肺炎的单药疗效。
Antimicrob Agents Chemother. 1996 Apr;40(4):962-5. doi: 10.1128/AAC.40.4.962.
4
Limited effect of trimethoprim-sulfamethoxazole prophylaxis on Pneumocystis carinii.甲氧苄啶-磺胺甲恶唑预防对卡氏肺孢子虫的作用有限。
Antimicrob Agents Chemother. 1979 Sep;16(3):333-5. doi: 10.1128/AAC.16.3.333.
5
Efficacy of a hydroxynaphthoquinone, 566C80, in experimental Pneumocystis carinii pneumonitis.羟基萘醌566C80在实验性卡氏肺孢子虫肺炎中的疗效
Antimicrob Agents Chemother. 1990 Feb;34(2):225-8. doi: 10.1128/AAC.34.2.225.
6
Effects of aerosolized synthetic surfactant, atovaquone, and the combination of these on murine Pneumocystis carinii pneumonia.雾化合成表面活性剂、阿托伐醌及其组合对小鼠卡氏肺孢子虫肺炎的影响。
J Infect Dis. 1998 Apr;177(4):1046-56. doi: 10.1086/515252.
7
Effects of sulfonylurea compounds on Pneumocystis carinii.
J Infect Dis. 1986 May;153(5):944-7. doi: 10.1093/infdis/153.5.944.
8
Atovaquone compared with dapsone for the prevention of Pneumocystis carinii pneumonia in patients with HIV infection who cannot tolerate trimethoprim, sulfonamides, or both. Community Program for Clinical Research on AIDS and the AIDS Clinical Trials Group.对于不能耐受甲氧苄啶、磺胺类药物或两者的HIV感染患者，用阿托伐醌与氨苯砜预防卡氏肺孢子虫肺炎的比较。艾滋病临床研究社区项目和艾滋病临床试验组。
N Engl J Med. 1998 Dec 24;339(26):1889-95. doi: 10.1056/NEJM199812243392604.
9
Intermittent trimethoprim-sulfamethoxazole compared with dapsone-pyrimethamine for the simultaneous primary prophylaxis of Pneumocystis pneumonia and toxoplasmosis in patients infected with HIV.与氨苯砜-乙胺嘧啶相比，间断使用甲氧苄啶-磺胺甲恶唑对感染HIV患者同时进行肺孢子菌肺炎和弓形虫病的原发性预防。
Ann Intern Med. 1995 May 15;122(10):755-61. doi: 10.7326/0003-4819-122-10-199505150-00004.
10
Surfactant phospholipids and lavage phospholipase A2 in experimental Pneumocystis carinii pneumonia.实验性卡氏肺孢子虫肺炎中的表面活性物质磷脂和灌洗磷脂酶A2
Am Rev Respir Dis. 1986 Sep;134(3):526-31. doi: 10.1164/arrd.1986.134.3.526.
引用本文的文献
1
Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites.聚醚离子载体：广谱且有前途的生物活性分子，可用于控制耐药细菌和寄生虫。
Expert Opin Drug Discov. 2009 Feb;4(2):109-46. doi: 10.1517/17460440802661443.
2
"Human babesiosis": an emerging transfusion dilemma.“人类巴贝斯虫病”：一个新出现的输血难题。
Int J Hepatol. 2012;2012:431761. doi: 10.1155/2012/431761. Epub 2012 Mar 28.
3
Short-term exposure to membrane-active antibiotics inhibits Cryptosporidium parvum infection in cell culture.
Antimicrob Agents Chemother. 2000 Dec;44(12):3473-5. doi: 10.1128/AAC.44.12.3473-3475.2000.
本文引用的文献
1
Effect of sex and dexamethasone dose on the experimental host for Pneumocystis carinii.
Lab Anim Sci. 1996 Feb;46(1):109-10.
2
Anticryptosporidial activity of lasalocid and other ionophorous antibiotics in immunosuppressed rats.
J Infect Dis. 1993 Dec;168(6):1566-9. doi: 10.1093/infdis/168.6.1566.
3
Toxic effects of lasalocid in horses.拉沙洛西对马的毒性作用。
Am J Vet Res. 1981 Mar;42(3):456-61.
4
Studies on the stage of action of ionophorous antibiotics against Eimeria.离子载体类抗生素对艾美耳球虫作用阶段的研究。
J Parasitol. 1982 Jun;68(3):363-71.
5
A literature review on the toxicity of lasalocid, a polyether antibiotic.
Vet Hum Toxicol. 1984 Aug;26(4):322-6.
6
Efficacy of diaminodiphenylsulfone and other drugs in murine Pneumocystis carinii pneumonitis.二氨基二苯砜及其他药物对鼠卡氏肺孢子虫肺炎的疗效
Antimicrob Agents Chemother. 1984 Oct;26(4):436-40. doi: 10.1128/AAC.26.4.436.
7
Biosynthesis of lasalocid. III. Isolation and structure determination of four homologs of lasalocid A.拉沙洛西的生物合成。III. 拉沙洛西A的四种同系物的分离与结构测定。
J Antibiot (Tokyo). 1974 Oct;27(10):744-53. doi: 10.7164/antibiotics.27.744.
8
Efficacy of trimethoprim and sulfamethoxazole in the prevention and treatment of Pneumocystis carinii pneumonitis.甲氧苄啶和磺胺甲恶唑在预防和治疗卡氏肺孢子虫肺炎中的疗效。
Antimicrob Agents Chemother. 1974 Mar;5(3):289-93. doi: 10.1128/AAC.5.3.289.
9
Successful treatment with aerosolized pentamidine of Pneumocystis carinii pneumonia in rats.雾化喷他脒成功治疗大鼠卡氏肺孢子虫肺炎。
Antimicrob Agents Chemother. 1987 Jan;31(1):37-41. doi: 10.1128/AAC.31.1.37.
10
Activity of clindamycin with primaquine against Pneumocystis carinii in vitro and in vivo.克林霉素与伯氨喹联合应用对卡氏肺孢子虫的体内外活性
Antimicrob Agents Chemother. 1988 Jun;32(6):807-13. doi: 10.1128/AAC.32.6.807.
Zotero 插件