Sköld C M, Blaschke E, Eklund A
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
Respir Med. 1996 Oct;90(9):523-9. doi: 10.1016/s0954-6111(96)90144-4.
Inhalation of tobacco smoke results in an accumulation of cells in the lower respiratory tract. The inflammatory response in the alveoli and lung interstitium may also be reflected by increased bronchoalveolar lavage (BAL) fluid concentrations of extracellular matrix components. The present study investigated the influence of smoking on the BAL fluid concentrations of albumin (ALB), hyaluronan (HA) and fibronectin (FN). Lavage fluids from 18 smokers were analysed before and at 1, 3, 6, 9 and 15 months after smoking cessation. Never-smokers (n = 112) served as a reference group. The total cell concentration and the concentrations of macrophages, lymphocytes, neutrophils and eosinophils were higher (P < 0.001-0.01) in smokers' BAL fluid than in never-smokers', but the values returned to normal within 9 months of smoking cessation. The HA concentration was higher (P < 0.001) in smokers' than in never-smokers' BAL fluid, but FN and ALB did not differ. Transient increases in the concentrations of ALB and HA (P < 0.01 for both) was observed within 6 months of smoking cessation. These findings indicate a temporary heightened alveolar-capillary permeability and an increased production and/or degradation of HA, being enhanced following smoking cessation. The findings probably reflect an initiation of a reparative process.
吸入烟草烟雾会导致下呼吸道细胞积聚。肺泡和肺间质中的炎症反应也可能通过支气管肺泡灌洗（BAL）液中细胞外基质成分浓度的增加而体现出来。本研究调查了吸烟对BAL液中白蛋白（ALB）、透明质酸（HA）和纤连蛋白（FN）浓度的影响。对18名吸烟者戒烟前以及戒烟后1、3、6、9和15个月的灌洗液进行了分析。从不吸烟者（n = 112）作为参照组。吸烟者BAL液中的总细胞浓度以及巨噬细胞、淋巴细胞、中性粒细胞和嗜酸性粒细胞的浓度均高于从不吸烟者（P < 0.001 - 0.01），但这些值在戒烟后9个月内恢复正常。吸烟者BAL液中的HA浓度高于从不吸烟者（P < 0.001），但FN和ALB无差异。戒烟后6个月内观察到ALB和HA浓度出现短暂升高（两者P均 < 0.01）。这些发现表明肺泡 - 毛细血管通透性暂时升高，HA的产生和/或降解增加，且在戒烟后增强。这些发现可能反映了修复过程的启动。
