一种用于诊断新生儿衣原体性结膜炎的新型光学免疫测定法的评估。
Evaluation of a new optical immunoassay for diagnosis of neonatal chlamydial conjunctivitis.
作者信息
Roblin P M, Gelling M, Kutlin A, Tsumura N, Hammerschlag M R
机构信息
Department of Pediatrics, State University of New York Health Science Center at Brooklyn, New York 11203-2098, USA.
出版信息
J Clin Microbiol. 1997 Feb;35(2):515-6. doi: 10.1128/jcm.35.2.515-516.1997.
The BioStar OIA Chlamydia test (BioStar, Inc., Boulder, Colo.) is a novel immunoassay system that uses changes in reflection of light to directly detect chlamydial antigen in clinical specimens. We compared the optical immunoassay (OIA) with culture for detecting Chlamydia trachomatis in ocular specimens from infants with suspected chlamydial conjunctivitis. We initially performed a retrospective evaluation, testing 152 ocular specimens previously collected for culture with the OIA. The sensitivity and specificity were 94.2 and 97%, respectively. A subsequent prospective study evaluating 37 ocular specimens from infants with suspected C. trachomatis conjunctivitis revealed a sensitivity and specificity of 100 and 92.6%, respectively.
BioStar OIA衣原体检测（BioStar公司，科罗拉多州博尔德市）是一种新型免疫分析系统，它利用光反射的变化直接检测临床标本中的衣原体抗原。我们将光学免疫分析（OIA）与培养法进行比较，以检测疑似衣原体性结膜炎婴儿眼部标本中的沙眼衣原体。我们首先进行了一项回顾性评估，用OIA检测之前收集用于培养的152份眼部标本。敏感性和特异性分别为94.2%和97%。随后一项前瞻性研究评估了37份疑似沙眼衣原体结膜炎婴儿的眼部标本，结果显示敏感性和特异性分别为100%和92.6%。
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