化学发光免疫分析法与培养法在诊断婴儿衣原体感染中的比较。
Comparison of a chemiluminometric immunoassay with culture for diagnosis of chlamydial infections in infants.
作者信息
Dumornay W, Roblin P M, Gelling M, Hammerschlag M R, Worku M
机构信息
Department of Pediatrics and Medicine, State University of New York Health Science Center, Brooklyn 11203.
出版信息
J Clin Microbiol. 1992 Jul;30(7):1867-9. doi: 10.1128/jcm.30.7.1867-1869.1992.
The performance of Magic Lite (CIBA-Corning), a chemiluminescent immunoassay (CIA), was compared with that of culture for the diagnosis of neonatal chlamydial conjunctivitis and respiratory infection. We performed a retrospective evaluation of 51 ocular and 96 nasopharyngeal specimens previously collected for culture testing with the CIA. The sensitivities for the ocular and the nasopharyngeal specimens were 91 and 91.7%, respectively. The specificities for both sites were 100%. A subsequent prospective study evaluating 71 ocular and 38 nasopharyngeal specimens revealed sensitivities of 83.3 and 20%, respectively. The specificities for both sites were 100%. The CIA performed favorably, compared with culture, for the diagnosis of chlamydial conjunctivitis; however, the CIA appeared less sensitive for the diagnosis of respiratory infection, including pneumonia.
为诊断新生儿衣原体性结膜炎和呼吸道感染，对化学发光免疫分析（CIA）——Magic Lite（CIBA - Corning）的性能与培养法进行了比较。我们对之前收集用于培养检测的51份眼部标本和96份鼻咽部标本进行了回顾性评估。眼部标本和鼻咽部标本的敏感性分别为91%和91.7%。两个部位的特异性均为100%。随后一项评估71份眼部标本和38份鼻咽部标本的前瞻性研究显示，敏感性分别为83.3%和20%。两个部位的特异性均为100%。与培养法相比，CIA在诊断衣原体性结膜炎方面表现良好；然而，CIA在诊断包括肺炎在内的呼吸道感染方面似乎敏感性较低。
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