墨西哥利什曼原虫无鞭毛体分泌的蛋白聚糖可导致巨噬细胞形成液泡。
Proteophosphoglycan secreted by Leishmania mexicana amastigotes causes vacuole formation in macrophages.
作者信息
Peters C, Stierhof Y D, Ilg T
机构信息
Max-Planck-Institut für Biologie, Abteilung Membranbiochemie, Tübingen, Germany.
出版信息
Infect Immun. 1997 Feb;65(2):783-6. doi: 10.1128/iai.65.2.783-786.1997.
Abstract
The amastigote form of Leishmania mexicana parasites colonizes macrophage phagolysosomes and induces the enlargement of these compartments to form huge parasitophorous vacuoles. We report here that a purified secreted amastigote product, proteophosphoglycan, is a macromolecule which causes vacuolization of peritoneal macrophages in vitro. Secretion of this glycoconjugate by intracellular parasites may contribute to the expansion of phagolysosomal compartments in infected cells.
摘要
墨西哥利什曼原虫寄生虫的无鞭毛体形式定殖于巨噬细胞吞噬溶酶体，并诱导这些区室扩大以形成巨大的寄生泡。我们在此报告，一种纯化的分泌型无鞭毛体产物，即蛋白磷酸聚糖，是一种在体外可导致腹膜巨噬细胞空泡化的大分子。细胞内寄生虫分泌这种糖缀合物可能有助于受感染细胞中吞噬溶酶体区室扩大。
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