Takizawa H, Satoh M, Okazaki H, Matsuzaki G, Suzuki N, Ishii A, Suko M, Okudaira H, Morita Y, Ito K
Department of Medicine and Physical Therapy, University of Tokyo, School of Medicine, Hongo, Japan.
Clin Exp Immunol. 1997 Jan;107(1):175-81. doi: 10.1046/j.1365-2249.1997.d01-905.x.
A variety of cytokines have been implicated in the pathogenesis of pulmonary sarcoidosis, but the exact roles of IL-6 and IL-8 are not yet clear. We studied these cytokine levels in BALF from patients with pulmonary sarcoidosis, idiopathic pulmonary fibrosis (IPF), systemic screlosis (SSc) with interstitial lung disease and control subjects. IL-6 and IL-8 levels were significantly elevated in sarcoidosis, IPF and SSc with interstitial lung disease compared with control subjects. Subjects with sarcoidosis had significantly increased levels of both cytokines compared with controls when the cytokine values were corrected by the total albumin content and the two cytokine levels correlated with each other (r = 0.876). BALF IL-6 levels correlated with percent lymphocytes and percent CD3+ cells. Moreover, when sarcoidosis patients were divided into three groups, those who needed steroid therapy or had progressive disease showed increased cytokine levels in BALF over stable or improved patients. These observations suggest that locally derived IL-6 and IL-8 were increased in sarcoidosis and correlated with activity of this granulomatous lung disease.
多种细胞因子与肺结节病的发病机制有关，但白细胞介素-6（IL-6）和白细胞介素-8（IL-8）的确切作用尚不清楚。我们研究了肺结节病患者、特发性肺纤维化（IPF）患者、合并间质性肺病的系统性硬化症（SSc）患者以及对照受试者支气管肺泡灌洗液（BALF）中的这些细胞因子水平。与对照受试者相比，结节病、IPF和合并间质性肺病的SSc患者的IL-6和IL-8水平显著升高。当通过总白蛋白含量校正细胞因子值时，结节病患者的两种细胞因子水平均显著高于对照组，且两种细胞因子水平相互相关（r = 0.876）。BALF中的IL-6水平与淋巴细胞百分比和CD3+细胞百分比相关。此外，当将结节病患者分为三组时，那些需要类固醇治疗或患有进行性疾病的患者，其BALF中的细胞因子水平高于病情稳定或改善的患者。这些观察结果表明，结节病中局部产生的IL-6和IL-8增加，且与这种肉芽肿性肺病的活动相关。
