Karp P D, Riley M, Paley S M, Pellegrini-Toole A, Krummenacker M
Artificial Intelligence Center, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.
Nucleic Acids Res. 1997 Jan 1;25(1):43-51. doi: 10.1093/nar/25.1.43.
The Encyclopedia of Genes and Metabolism (EcoCyc) is a database that combines information about the genome and the intermediary metabolism of Escherichia coli. It describes 2970 genes of E.coli, 547 enzymes encoded by these genes, 702 metabolic reactions that occur in E.coli and the organization of these reactions into 107 metabolic pathways. The EcoCyc graphical user interface allows scientists to query and explore the EcoCyc database using visualization tools such as genomic-map browsers and automatic layouts of metabolic pathways. EcoCyc spans the space from sequence to function to allow scientists to investigate an unusually broad range of questions. EcoCyc can be thought of as both an electronic review article because of its copious references to the primary literature, and as an in silicio model of E.coli metabolism that can be probed and analyzed through computational means.
《基因与代谢百科全书》（EcoCyc）是一个整合了大肠杆菌基因组信息和中间代谢信息的数据库。它描述了大肠杆菌的2970个基因、这些基因编码的547种酶、大肠杆菌中发生的702种代谢反应以及这些反应如何组织成107条代谢途径。EcoCyc的图形用户界面使科学家能够使用诸如基因组图谱浏览器和代谢途径自动布局等可视化工具来查询和探索EcoCyc数据库。EcoCyc跨越了从序列到功能的范围，使科学家能够研究异常广泛的问题。由于其对原始文献的大量引用，EcoCyc既可以被视为一篇电子综述文章，也可以被视为一个大肠杆菌代谢的计算机模拟模型，可通过计算手段进行探究和分析。
