Karp P D, Riley M, Paley S M, Pellegrini-Toole A, Krummenacker M
Artificial Intelligence Center, SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.
Nucleic Acids Res. 1998 Jan 1;26(1):50-3. doi: 10.1093/nar/26.1.50.
The encyclopedia of Escherichia coli genes and metabolism (EcoCyc) is a database that combines information about the genome and the intermediary metabolism of E.coli. The database describes 3030 genes of E.coli , 695 enzymes encoded by a subset of these genes, 595 metabolic reactions that occur in E.coli, and the organization of these reactions into 123 metabolic pathways. The EcoCyc graphical user interface allows scientists to query and explore the EcoCyc database using visualization tools such as genomic-map browsers and automatic layouts of metabolic pathways. EcoCyc can be thought of as an electronic review article because of its copious references to the primary literature, and as a (qualitative) computational model of E.coli metabolism. EcoCyc is available at URL http://ecocyc.PangeaSystems.com/ecocyc/
大肠杆菌基因与代谢百科全书(EcoCyc)是一个整合了大肠杆菌基因组信息和中间代谢信息的数据库。该数据库描述了大肠杆菌的3030个基因、其中一部分基因编码的695种酶、大肠杆菌中发生的595种代谢反应,以及这些反应被组织成的123条代谢途径。EcoCyc图形用户界面使科学家能够使用诸如基因组图谱浏览器和代谢途径自动布局等可视化工具来查询和探索EcoCyc数据库。由于EcoCyc大量引用了原始文献,它可以被视为一篇电子综述文章,同时也可作为大肠杆菌代谢的(定性)计算模型。可通过网址http://ecocyc.PangeaSystems.com/ecocyc/访问EcoCyc。