O'Connell D J, Bennett R M
Br J Radiol. 1977 Sep;50(597):620-5. doi: 10.1259/0007-1285-50-597-620.
The clinical and radiological features of 20 cases of mixed connective tissue disease (MCTD), a newly defined disorder, are described. MCTD shares a number of abnormalities with other collagen diseases, notably diffuse systemic sclerosis and systemic lupus erythematosus. However, patients with MCTD have a specific circulating antibody to extractable nuclear antigen (ENA). Most of the cases described exhibited multi-system involvement with radiological changes in the skeleton, chest, and gastro-intestinal tract. Twelve of the 20 cases had an erosive arthritis. This finding has not been previously noted in the radiological literature.
本文描述了20例混合性结缔组织病（MCTD）的临床和放射学特征，这是一种新定义的疾病。MCTD与其他胶原病有许多异常相似之处，尤其是弥漫性系统性硬化症和系统性红斑狼疮。然而，MCTD患者有一种针对可提取核抗原（ENA）的特异性循环抗体。所描述的大多数病例表现为多系统受累，骨骼、胸部和胃肠道有放射学改变。20例中有12例患有侵蚀性关节炎。这一发现以前在放射学文献中未曾提及。
