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良性或恶性卵巢或子宫内膜肿瘤患者的皮下、网膜及肿瘤脂肪酸组成以及血清胰岛素状态。肿瘤是否优先利用多不饱和脂肪酸?

Subcutaneous, omentum and tumor fatty acid composition, and serum insulin status in patients with benign or cancerous ovarian or endometrial tumors. Do tumors preferentially utilize polyunsaturated fatty acids?

作者信息

Yam D, Ben-Hur H, Dgani R, Fink A, Shani A, Berry E M

机构信息

The Weizmann Institute of Science, Department of Membrane and Biophysics, Rehovot, Israel.

出版信息

Cancer Lett. 1997 Jan 1;111(1-2):179-85. doi: 10.1016/s0304-3835(96)04530-2.

DOI:10.1016/s0304-3835(96)04530-2
PMID:9022144
Abstract

The relationships between the fatty acid composition of cancerous endometrium and ovary, and peripheral adipose tissues were studied in Israeli Jewish women, and are presented together since no differences were shown between them. The results suggest a mobilization of linoleic acid from subcutaneous and omental depots and its incorporation into tumors accompanied by a high degree of desaturation. High blood insulin concentrations characterized patients with stage I and II disease, and low concentrations characterized patients with advanced degrees of malignancy.

摘要

在以色列犹太女性中研究了癌性子宫内膜和卵巢以及外周脂肪组织的脂肪酸组成之间的关系,由于未发现它们之间存在差异,因此一并呈现研究结果。结果表明,亚油酸从皮下和网膜脂肪库中被动员出来并掺入肿瘤,同时伴随着高度的去饱和作用。I期和II期疾病患者的血液胰岛素浓度较高,而恶性程度较高的患者血液胰岛素浓度较低。

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引用本文的文献

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Int J Mol Sci. 2023 Jan 16;24(2):1768. doi: 10.3390/ijms24021768.
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Low Levels of Omega-3 Long-Chain Polyunsaturated Fatty Acids Are Associated with Bone Metastasis Formation in Premenopausal Women with Breast Cancer: A Retrospective Study.低水平的ω-3 长链多不饱和脂肪酸与绝经前乳腺癌女性的骨转移形成相关:一项回顾性研究。
Nutrients. 2020 Dec 15;12(12):3832. doi: 10.3390/nu12123832.
3
Linoleic Acid: A Nutritional Quandary.
亚油酸:一个营养难题。
Healthcare (Basel). 2017 May 20;5(2):25. doi: 10.3390/healthcare5020025.
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Omentum and bone marrow: how adipocyte-rich organs create tumour microenvironments conducive for metastatic progression.大网膜和骨髓:富含脂肪细胞的器官如何创造有利于转移进展的肿瘤微环境。
Obes Rev. 2016 Nov;17(11):1015-1029. doi: 10.1111/obr.12450. Epub 2016 Jul 19.
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Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment.卵巢癌微环境中脂肪酸配体对肿瘤相关巨噬细胞中PPARβ/δ靶基因的调控异常
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