Yam D, Ben-Hur H, Fink A, Dgani R, Shani A, Eliraz A, Insler V, Berry E M
Weizmann Institute of Science, Rehovot, Israel.
Br J Cancer. 1994 Dec;70(6):1186-7. doi: 10.1038/bjc.1994.470.
The relationship between tumour growth, insulin status, blood lipids and adipose linoleic acid (LA, reflecting long-term LA intake) was studied in 19 Jewish women suffering from early and advanced stages (ES and AS) of ovarian and endometrial tumours. Blood insulin in patients with ES tumours was four times higher than the control value in cancer-free subjects, but fell to normal levels at AS and after ES surgery (PES). Tumours and abdominal adipose tissue (AAT) had 4-6 and 1.4-1.7 times as much insulin as non-cancerous control organs. Serum total cholesterol (CHOL) and LDL-cholesterol were high at ES, dropped below normal at AS, but normalised at PES, while HDL-cholesterol increased after ES surgery. Linoleic acid in subcutaneous adipose tissue (SAT) was high in controls (26.4 + 1.5% of total fatty acids), but lower in cancer patients (20.5 + 3.7%, P < 0.05), while palmitic acid showed the opposite change. The results suggest mobilisation of glucose, cholesterol and linoleic acid for the supply of energy and structural lipids to rapidly multiplying tumour cells and possibly for prostaglandin synthesis. They also raise the question of whether the high linoleic acid intake by the Jewish population in Israel predisposes individuals to tumour development.
对19名患有早期和晚期卵巢及子宫内膜肿瘤的犹太女性，研究了肿瘤生长、胰岛素状态、血脂与脂肪组织亚油酸（LA，反映长期LA摄入量）之间的关系。早期肿瘤患者的血液胰岛素水平比无癌对照者的对照值高四倍，但在晚期及早期手术后（PES）降至正常水平。肿瘤和腹部脂肪组织（AAT）中的胰岛素含量分别是非癌对照器官的4 - 6倍和1.4 - 1.7倍。早期血清总胆固醇（CHOL）和低密度脂蛋白胆固醇水平较高，晚期降至正常水平以下，但在PES时恢复正常，而高密度脂蛋白胆固醇在早期手术后升高。皮下脂肪组织（SAT）中的亚油酸在对照组中含量较高（占总脂肪酸的26.4 + 1.5%），但在癌症患者中较低（20.5 + 3.7%，P < 0.05），而棕榈酸则呈现相反的变化。结果表明，为快速增殖的肿瘤细胞提供能量和结构脂质，以及可能用于前列腺素合成，会动员葡萄糖、胆固醇和亚油酸。这也提出了一个问题，即以色列犹太人群中亚油酸摄入量高是否会使个体易患肿瘤。
