Ji B T, Chow W H, Hsing A W, McLaughlin J K, Dai Q, Gao Y T, Blot W J, Fraumeni J F
Division of Epidemiology, Columbia University, School of Public Health, New York, NY, USA.
Int J Cancer. 1997 Jan 27;70(3):255-8. doi: 10.1002/(sici)1097-0215(19970127)70:3<255::aid-ijc1>3.0.co;2-w.
The effect of green tea drinking in reducing human cancer risk is unclear, though a protective effect has been reported in numerous animal studies and several epidemiologic investigations. Herein the hypothesis that green tea consumption may reduce the risk of cancers of the colon, rectum and pancreas is examined in a large population-based case-control study conducted in Shanghai, China. Newly diagnosed cancer cases (931 colon, 884 rectum and 451 pancreas) during 1990-1993 among residents 30-74 years of age were included. Controls (n = 1,552) were selected among Shanghai residents and frequency-matched to cases by gender and age. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) of each cancer associated with green tea consumption were derived after adjustment for age, income, education and cigarette smoking. Additional adjustment for dietary items and body size was found to have minimal impact. An inverse association with each cancer was observed with increasing amount of green tea consumption, with the strongest trends for rectal and pancreatic cancers. For men, compared with non-regular tea drinkers, ORs among those in the highest tea consumption category (> or = 300 g/month) were 0.82 for colon cancer, 0.72 for rectal cancer and 0.63 for pancreatic cancer, with p values for trend being 0.38, 0.04 and 0.04, respectively. For women, the respective ORs for the highest consumption category (> or = 200 g/month) were 0.67, 0.57 and 0.53, with the respective p values for trend being 0.07, 0.001 and 0.008. Our findings provide further evidence that green tea drinking may lower the risk of colorectal and pancreatic cancers.
尽管在众多动物研究和一些流行病学调查中报告了绿茶饮用对降低人类癌症风险具有保护作用，但这种作用尚不清楚。在此，在中国上海进行的一项基于人群的大型病例对照研究中，对饮用绿茶可能降低结肠癌、直肠癌和胰腺癌风险这一假设进行了检验。纳入了1990 - 1993年间30 - 74岁居民中新诊断的癌症病例（931例结肠癌、884例直肠癌和451例胰腺癌）。对照组（n = 1552）从上海居民中选取，并按性别和年龄与病例进行频数匹配。在对年龄、收入、教育程度和吸烟情况进行调整后，得出了与饮用绿茶相关的每种癌症的多变量优势比（OR）和95%置信区间（CI）。发现对饮食项目和体型进行额外调整的影响极小。随着绿茶饮用量增加，观察到与每种癌症呈负相关，其中直肠癌和胰腺癌的趋势最为明显。对于男性，与不经常饮茶者相比，最高饮茶量类别（≥300克/月）者的结肠癌OR为0.82，直肠癌OR为0.72，胰腺癌OR为0.63，趋势的p值分别为0.38、0.04和0.04。对于女性，最高饮用量类别（≥200克/月）者的相应OR分别为0.67、0.57和0.53，趋势的p值分别为0.07、0.001和0.008。我们的研究结果提供了进一步的证据，表明饮用绿茶可能降低结直肠癌和胰腺癌的风险。
