Han T S, Richmond P, Avenell A, Lean M E
Department of Human Nutrition, University of Glasgow, Glasgow Royal Infirmary, USA.
Int J Obes Relat Metab Disord. 1997 Feb;21(2):127-34. doi: 10.1038/sj.ijo.0800377.
To examine the relationship between waist circumference and cardiovascular risk factors during weight loss, and to consider possible waist reduction targets for weight management.
Single strand six month weight loss study on food based diets in 110 women aged 18-68 y, and body mass index > or = 25 kg/m2 set at an outpatient clinic.
Waist circumference, weight, body mass index (BMI), total plasma cholesterol, low (LDL) and high density lipoprotein (HDL) cholesterol, triglyceride, and blood pressure.
Anthropometric and metabolic measurements improved with mean weight loss of 4.9 (s.e.m. +/- 0.4) kg at three months and 6.2 (s.e.m. +/- 0.4) kg at six months. Weight loss closely related to waist reduction (% Weight loss = 0.85 x Waist reduction (cm)-2.09; r = 0.79). The proportion of subjects with waist circumference below Action Level 1 (< 80 cm) or above Action Level 2 (> or = 88 cm) were 9 and 60% at baseline, 29 and 38% at three months and 36 and 33% at six months. Waist reduction (adjusted for age, smoking, alcohol consumption, diet treatment and baseline dependent and independent variables) correlated significantly with falls in total cholesterol (r = 0.31; P < 0.01), LDL cholesterol (r = 0.35; P < 0.01) and diastolic blood pressure (r = 0.32; P < 0.01), but not significantly with HDL cholesterol, triglyceride or systolic blood pressure. BMI showed similar correlations, whereas waist to hip ratio changes were not associated with changes in any cardiovascular risk factors. Amongst those whose waist fell by > or = 5 cm, 45 at three months and 43 at six months, there were > or = 10% improvements in at least one risk factor for 71 and 84% respectively. Amongst those whose waist fell by 5-10 cm, 40 women at three months and 30 at six months, at least one risk factor improved by > or = 10% in 70% and in 83% respectively.
Waist reduction of 5-10 cm in Caucasian women, across a range of baseline BMI 25-50 kg/m2 or waist circumference 72-133 cm, may be used as guideline to encourage overweight women to achieve a realistic target with a high probability of health benefits.
研究减肥过程中腰围与心血管危险因素之间的关系，并探讨体重管理中可能的腰围降低目标。
在门诊对110名年龄在18 - 68岁、体重指数（BMI）≥25 kg/m²的女性进行为期6个月的基于食物饮食的单组减肥研究。
腰围、体重、体重指数（BMI）、总血浆胆固醇、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）胆固醇、甘油三酯以及血压。
人体测量和代谢指标有所改善，三个月时平均体重减轻4.9（标准误±0.4）kg，六个月时平均体重减轻6.2（标准误±0.4）kg。体重减轻与腰围减小密切相关（体重减轻百分比 = 0.85×腰围减小量（cm） - 2.09；r = 0.79）。腰围低于行动水平1（<80 cm）或高于行动水平2（≥88 cm）的受试者比例在基线时分别为9%和60%，三个月时为29%和38%，六个月时为36%和33%。腰围减小（根据年龄、吸烟、饮酒、饮食治疗以及基线相关和独立变量进行调整）与总胆固醇降低（r = 0.31；P < 0.01）、低密度脂蛋白胆固醇降低（r = 0.35；P < 0.01）和舒张压降低（r = 0.32；P < 0.01）显著相关，但与高密度脂蛋白胆固醇、甘油三酯或收缩压无显著相关性。BMI显示出类似的相关性，而腰臀比变化与任何心血管危险因素的变化均无关联。在腰围至少减小≥5 cm的人群中，三个月时有45人，六个月时有43人，至少一种危险因素改善≥10%的比例分别为71%和84%。在腰围减小5 - 10 cm的人群中，三个月时有40名女性，六个月时有30名女性，至少一种危险因素改善≥10%的比例分别为70%和83%。
对于基线BMI在25 - 50 kg/m²或腰围在72 - 133 cm范围内的白人女性，腰围减小5 - 10 cm可作为指导方针，鼓励超重女性实现一个具有较高健康益处可能性的现实目标。
