2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶对雌性斯普拉格-道利大鼠的剂量依赖性乳腺癌诱导作用。
Dose-dependent induction of mammary carcinomas in female Sprague-Dawley rats with 2-amino-1-methyl-6-phenylimidazol[4,5-b]pyridine.
作者信息
Imaida K, Hagiwara A, Yada H, Masui T, Hasegawa R, Hirose M, Sugimura T, Ito N, Shirai T
机构信息
First Department of Pathology, Nagoya City University Medical School, Mizuho-ku.
出版信息
Jpn J Cancer Res. 1996 Nov;87(11):1116-20. doi: 10.1111/j.1349-7006.1996.tb03120.x.
Abstract
The dose-dependence of 2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induction of mammary carcinomas was investigated in female Sprague-Dawley (SD) rats given PhIP in the diet for 48 weeks at concentrations of 0, 25, 100 and 200 ppm in experiment 1, and 0, 12.5, 50 in experiment 2. Yields of ductular lesions, including intraductal papillomas and carcinomas, as well as papillo-tubular and solid-tubular carcinomas, showed dependence on the dose, with the respective total incidences being 0, 4.8, 25, 72.2 and 0, 10 and 35%. There was thus no apparent carcinogen exposure threshold. The present results confirmed the carcinogenicity demonstrated in a previous study using F344 rats and revealed the SD rat strain to be more susceptible.
摘要
在实验1中，给雌性斯普拉格-道利（SD）大鼠喂食含2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶（PhIP）的饲料，浓度分别为0、25、100和200 ppm，持续48周；在实验2中，浓度分别为0、12.5、50 ppm，以此研究PhIP诱导乳腺癌的剂量依赖性。包括导管内乳头状瘤和癌以及乳头管状癌和实体管状癌在内的导管病变发生率显示出对剂量的依赖性，各自的总发生率分别为0、4.8%、25%、72.2%以及0、10%和35%。因此，没有明显的致癌物暴露阈值。本研究结果证实了先前使用F344大鼠的研究中所证明的致癌性，并表明SD大鼠品系更易患癌。
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