Agata H, Kondo N, Fukutomi O, Takemura M, Tashita H, Kobayashi Y, Shinoda S, Nishida T, Shinbara M, Orii T
Department of Pediatrics, Gifu University School of Medicine, Japan.
Ann Allergy Asthma Immunol. 1997 Feb;78(2):233-7. doi: 10.1016/S1081-1206(10)63394-7.
Adverse reactions after ingesting buckwheat are known to be IgE-mediated. Further, hypersensitivity reactions may be involved in some patients with pulmonary hemosiderosis related to cow milk sensitivity. We, however, encountered a patient with pulmonary hemosiderosis related to buckwheat protein without high levels of buckwheat-specific IgE antibodies.
The aim of this study was to investigate the mechanisms.
RAST for anti-buckwheat IgE, skin prick test, skin patch test, and proliferative responses of peripheral blood mononuclear cells to buckwheat were investigated in this patient.
RAST values for buckwheat protein were negative, and skin prick test for buckwheat protein also gave negative results. On the other hand, skin patch testing for buckwheat protein elicited positive responses. Further, peripheral blood mononuclear cells of our patient responded to buckwheat protein.
Our patient had pulmonary hemosiderosis related to non-immediate buckwheat protein hypersensitivity.
已知摄入荞麦后的不良反应是由IgE介导的。此外，超敏反应可能与一些对牛奶敏感相关的肺含铁血黄素沉着症患者有关。然而，我们遇到了一名与荞麦蛋白相关的肺含铁血黄素沉着症患者，其体内荞麦特异性IgE抗体水平并不高。
本研究旨在探讨其机制。
对该患者进行了抗荞麦IgE的放射变应原吸附试验（RAST）、皮肤点刺试验、皮肤斑贴试验以及外周血单个核细胞对荞麦的增殖反应研究。
荞麦蛋白的RAST值为阴性，荞麦蛋白的皮肤点刺试验结果也为阴性。另一方面，荞麦蛋白的皮肤斑贴试验引发了阳性反应。此外，我们患者的外周血单个核细胞对荞麦蛋白有反应。
我们的患者患有与非速发型荞麦蛋白超敏反应相关的肺含铁血黄素沉着症。
