粪肠球菌临床分离株中存在的质粒的高水平质粒介导庆大霉素耐药性及信息素反应
High-level plasmid-mediated gentamicin resistance and pheromone response of plasmids present in clinical isolates of Enterococcus faecalis.
作者信息
Shiojima M, Tomita H, Tanimoto K, Fujimoto S, Ike Y
机构信息
Department of Microbiology, Gunma University School of Medicine, Japan.
出版信息
Antimicrob Agents Chemother. 1997 Mar;41(3):702-5. doi: 10.1128/AAC.41.3.702.
Abstract
Eleven pheromone-responding plasmids encoding erythromycin or gentamicin resistance were isolated from multiresistant clinical Enterococcus faecalis isolates. The plasmids were classified into six types with respect to their pheromone responses. The three erythromycin resistance plasmids responded to different pheromones. Of the eight gentamicin resistance plasmids, four plasmids responded to same pheromone. Southern hybridization studies showed that the genes involved in regulation of the pheromone response were conserved in the drug resistance plasmids.
摘要
从多重耐药的临床粪肠球菌分离株中分离出11个编码红霉素或庆大霉素抗性的信息素反应质粒。这些质粒根据其信息素反应分为六种类型。三种红霉素抗性质粒对不同的信息素产生反应。在八个庆大霉素抗性质粒中，有四个质粒对相同的信息素产生反应。Southern杂交研究表明，参与信息素反应调节的基因在耐药质粒中是保守的。
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