念珠菌在婴儿抗生素相关性腹泻间接发病机制中的作用。

Role of Candida in indirect pathogenesis of antibiotic associated diarrhoea in infants.

作者信息

Ponnuvel K M, Rajkumar R, Menon T, Sankaranarayanan V S

机构信息

Department of Microbiology, Dr. ALM. P.G. Institute of Basic Medical Sciences, Taramani, Madras, India.

出版信息

Mycopathologia. 1996;135(3):145-7. doi: 10.1007/BF00632335.

DOI:10.1007/BF00632335

PMID:9066155

Abstract

One hundred and thirty seven isolates of Candida species were isolated from antibiotic associated diarrhoea cases and were examined to study the role of Candida in the pathogenesis of diarrhoea in infants. The quantitative estimation of yeast population by simple gram stain smear revealed more than 70% of the cases had 3+ score. The isolates further screened for detection of beta-lactamases. Among the isolated Candida sp, beta-lactamases was secreted by C. albicans, C. tropicalis, C. krusei and C. parapsilosis. Further, 46% of the Candida isolates were found to be produced 741-1110 mU/ml of beta-lactamases, suggesting that these enzyme would inactivate penicillin group of drugs and cause failure in the therapy directed against other diarrhoegenic bacteria.

摘要

从抗生素相关性腹泻病例中分离出137株念珠菌属菌株，并对其进行检测，以研究念珠菌在婴儿腹泻发病机制中的作用。通过简单的革兰氏染色涂片对酵母菌群进行定量估计，结果显示超过70%的病例评分为3+。对分离出的菌株进一步筛查β-内酰胺酶。在分离出的念珠菌属中，白色念珠菌、热带念珠菌、克柔念珠菌和近平滑念珠菌可分泌β-内酰胺酶。此外，发现46%的念珠菌分离株产生741-1110 mU/ml的β-内酰胺酶，这表明这些酶会使青霉素类药物失活，并导致针对其他致泻性细菌的治疗失败。