Ariffin S A, Whyte J A, Malins A F, Cooper G M
Featherstone Department of Anaesthesia, Queen Elizabeth Hospital, Edgbaston, Birmingham.
Br J Anaesth. 1997 Feb;78(2):157-9. doi: 10.1093/bja/78.2.157.
We have compared sevoflurane and halothane in a double-blind controlled study for supplementation of nitrous oxide and oxygen anaesthesia in 80 children undergoing dental extraction as outpatients. Induction of anaesthesia was more rapid in those who received sevoflurane compared with those who received halothane (89 s compared with 127 s for loss of eyelash reflex). In both groups, mean duration of administration of anaesthesia was less than 4 min. Those who received sevoflurane were slower to awaken (167 s compared with 102 s), although discharge times from hospital were similar. The incidence of complications during induction and maintenance was low in both groups and return to normal appetite and activity occurred in the majority of children on the same day. More children who received halothane suffered nausea after leaving hospital. We conclude that sevoflurane is a suitable alternative to halothane, with more rapid induction of anaesthesia, but in these short procedures, awakening time was slower than after halothane.
我们在一项双盲对照研究中,比较了七氟烷和氟烷对80名门诊接受拔牙手术儿童氧化亚氮和氧气麻醉的补充效果。与接受氟烷的儿童相比,接受七氟烷的儿童麻醉诱导更快(睫毛反射消失时间分别为89秒和127秒)。两组的平均麻醉给药时间均少于4分钟。接受七氟烷的儿童苏醒较慢(分别为167秒和102秒),不过出院时间相似。两组诱导和维持过程中并发症的发生率都很低,大多数儿童在同一天恢复正常食欲和活动。更多接受氟烷的儿童出院后出现恶心症状。我们得出结论,七氟烷是氟烷的合适替代品,麻醉诱导更快,但在这些短时间手术中,苏醒时间比氟烷麻醉后要慢。